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Doxycycline Hyclate vs Monohydrate? Differences?

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Posted 6/13/2016 6:48 AM (GMT 0)
I've heard that Doxy monohydrate is easier on the stomach and can be taken without food? Is that true? Is it just as effective as Hyclate or should I not risk it and stick with the "tried and true" original Doxy Hyclate? Thanks!
Posted 6/13/2016 1:40 PM (GMT 0)
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Posted 6/13/2016 3:10 PM (GMT 0)
Thats what I was told. My gut was pretty good all thought ABX usage, till Candida came out. There was a point where they switched those types of doxy's (for affordability) and it bothered my stomach a little.

When summer came by I changed from doxy to biaxin to avoid sun issues.

Hey- its summer, doxy might cause issues in the sun, you know this right?
Posted 6/13/2016 5:30 PM (GMT 0)
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Posted 6/13/2016 10:52 PM (GMT 0)
I'm not sure of its efficacy but the huckster did seem to be gentler on my stomach.
Posted 6/14/2016 1:45 AM (GMT 0)
hi there, as a pharmacist, yes, doxy monohydrate is not supposed to cause as much GI upset. However, the cost of this medicine is thru the roof, so most insurances won't pay for it.

I took the delayed release tablet form of doxycycline hyclate, that is your second best choice.

Also, whichever one you take, as long as you sandwich it in with food (eat first, take it, then eat again), it will help tremendously!
Posted 6/14/2016 7:30 AM (GMT 0)
interesting info thanks Chapelle. What is the name of the delayed release tablet form?

Also, does hyclate not get fully 100% absorbed if taken with food that has trace amounts of calcium, iron or magnesium?
Posted 6/14/2016 7:56 AM (GMT 0)
I've always been told that any slight reduction in absorption when taking with food is far outweighed by the importance of protecting our stomachs when we are taking these abx long-term.
Posted 6/14/2016 9:02 AM (GMT 0)
I did some research...Chapelle, is that one called Doryx? It's a capsule with little pellets of Doxy that dont dissolve in the stomach right? So its safe to take without food to avoid stomach damage?
Posted 6/15/2016 2:52 AM (GMT 0)
yes, it is doryx!

and my apologies, I took the doxy tablet - not the capsule, so I actually didn't take doryx. sorry for the mixup.

and no, unfortunately it is not safe to take without food! there is always a risk of esophageal erosion with doxy, especially for those who take it for extended periods. Doxy does not get affected by minerals such as iron and calcium in the same way tetracycline does. Most doctors don't know that, so you need not to worry.

I took doxy for a few months along with my vitamins, and believe me, it worked!! I had to stop taking it when i got to the 200mg twice a day dose, it became too toxic. I coudnt' handle it bc of the sun issues.
Posted 6/15/2016 5:53 AM (GMT 0)
i thought Doryx was safe to take w/o food because it disnt dissolve in the stomach? So how can it burn the esophagus? And what do u mean by too toxic? Im taking 200mg twice a day.
Posted 6/15/2016 7:46 AM (GMT 0)
I also took 200 mg twice daily of doxy.

It was tablet - I think they were orange?


I found them okay on my stomach - but I did take them with food.

I did have to take a break from them when we had a hot spell...it made my skin super sensitive to the sun.
Posted 6/15/2016 11:35 AM (GMT 0)
please don't be too frightened - any medication can become toxic if you take more than your body can handle. The 400mg daily dose of doxy was causing peripheral neuropathy as a side effect and my skin was getting burned from the sun.

yes, girlie, the tablet was definitely easier for me too.

floridadude - technically you are correct, yes, the delayed release form is supposed to bypass the stomach, and therefore not have a risk of esophageal erosion. However, I just caution everyone on here anyway bc we are all on such high doses and for a good length of time as opposed to a regular 2 week prescription. You can most certainly try doryx and not eat, and see what happens. But in my case, even when I ate I could not handle the doxy capsule, so when I switched to the tablet, although it was not DR, it did take longer to dissolve in my stomach than the capsule, and therefore caused less GI upset. Just remember that Doryx is very very expensive, maybe you will be fortunate enough and your insurance will cover it!!
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