Hard to Sleep at night due to "internal shaking"

I have this too! Went away for awhile and now back. I also just started glutathione (1,000 mg a day) and a few new detox things (sauna, byron white detox supps).

Don't know what causes this or how to fix. Sometimes it almost feels like my heart shaking but I'm pretty sure it's just some disconnect of my nervous system. My feet "buzz/vibrate" some during day but it's more chest/trunk/legs at night.

Lymenomore sometimes when you start jossling things around like you are with some of the therapies, you can feel worse. I can tell you that before I knew what was going on with me, I was doing acupuncture and it was great. Then all of a sudden it wasn't. I began to feel horrible after the sessions so I had to stop.

As far as the IV glutathione, what are they mixing in it? Can they just push it in with the syringe? Like a push every 5-7 minutes or so. Sometimes additives in the IV's don't agree with your body. I don't do well with a lot of saline. When it was mixed in my IV, I felt awful.

The problem with the glutiathone is that it can be converted to glutamate. When glutamate levels are high, it can lead to anxiety, manic-like symptoms, insomnia, and lowered GABA levels. When GABA is low, you're much more likely to have these anxiety-like symptoms. The only reason I know this is because I had a bad herx and treated it with a higher amount of glutiathone. Shortly after, it threw me into a "manic" cycle accompanied with the insomnia, racing thoughts, anxiety, etc. There is definitely a connection to excess glutiathone and these symptoms for me.

I've done a considerable amount of research on the glutamate/GABA conversion cycle. Lyme patients with excess toxins, heavy metals, etc, automatically have higher brain glutamate levels as it is. Let me know if this is confusing at all, and I'll try to explain a little more.

From Nancy Mullen, MD:
"If you keep the total amount of glutamate in your body under control, you can prevent neurologic symptoms. One way you can do this is by eliminating gluten and casein from your diet. You also want to eliminate glutamate and anything that sounds like that, and aspartate and anything that sounds like that, from your supplements.

Glutamine is a frequently recommended supplement, but glutamate and glutamine change back and forth into each other. This means that the administration of glutamine, say for gastro intestinal support, actually increases the level of glutamate.

There is a neurotransmitter, which opposes glutamate, which has a calming effect. This is GABA, gamma amino butyric acid. It is an inhibitory neurotransmitter. Glutamate should be able to convert into GABA.

Glutamate is acted on by the enzyme glutamic acid decarboxylase (GAD), but several factors may interfere with this conversion, and you get stuck at glutamate.

GABA is the neurotransmitter involved with this function. GABA is very prominently involved with the neuronal connections of language. It actually puts the gaps between words. Decreased GABA leads to increased anxiety, increased aggressive behavior, decreased social behavior, decreased eye contact, and decreased bowel function. GABA is necessary to stimulate bowel contraction.

Decreased GABA also causes eye-focusing problems, like both eyes focused in toward the nose or vertical or horizontal eye wavering.

Calcium is another factor in the glutamate GABA story. If glutamate is like a gun, then calcium is the bullet. Glutamate creates the scenario for excitotoxicity to happen, but the agent that actually destroys the nerve cell is the influx of calcium. The combination of excessive glutamate from any source and too much calcium is major.

Evaluate calcium levels using a urine essential elements test. Vitamin D and Vitamin K are fat-soluble vitamins and are important for re-establishing calcium balance. Your body can store Vitamin D, but Vitamin K may need to be supplemented on a daily basis unless you are eating dark leafy green organic vegetables.

Supplementing calcium may be done by using chamomile and/or nettle rather than by taking calcium directly. Increasing magnesium relative to calcium, using zinc to limit glutamate damage, and monitoring lithium, iodine and boron levels will all aid in reducing glutamate levels and reversing the flow of calcium into the neurons and back to the bones and teeth.

A common issue is taking too many supplements too soon. The more sick you are, the more carefully you need to add supplements. You should add them one at a time, starting with really tiny amounts."

Chinese cats claw , zanax and rocephin with ala ,glitithion has helped the vibrations ...lots of efa ,royal jelly lions mane...its bartonella

It can also be Bartonella - as it affects the nervous system.

Just for an update, I ended up going to Emergency Room other day for the internal shaking and insomnia. Did labs and I was a little low in potassium and my TSH was 4.33, which is high for me. They gave me some Potassium liquid to drink and as far as my TSH the doctor told me it was still in normal range but looks like I was going Hypothyroid, which my Lyme doctor already suspected that I was going hypothyroid. They suggested I up the dose of melatonin 1mg or prescription, which I chose to up Melatonin, don't like sleeping pills. When I got home, I felt more relaxed and some better. So I think some of it could have been low potassium. That night and for past 2 nights I've slept good and internal shaking has eased. I increased my melatonin to 2mg a night and that seemed to help. I believe I was dehydrated also, they gave me a IV saline. So now, I've got to decide to start back on Beyond Balance drops, Tox Ease GL, or try Nutramedix. I'm not sure if I can tolerate the Alcohol content in the Nutramedix. I started having the symptoms when I started the Nutramedix. The beyond balance doesn't have Alcohol, but so many different herbs. Well, I'll figure it out, just so I'm sleeping better. For a while there, I was not sleeping any at night, and that made my symptoms 100% worse. Everyone knows if you don't get your sleep, that will make Lymes worse. I believe that is the most important part of getting better with Lymes, your sleep. Your body heals itself while you are sleeping.

Thanks MA10. Yes a lot of people aren't aware of glutamate and glutamine issues. As you know it is a complex area when you get into pathways, etc.

I learned about the glutamine issue last year when I began to have reactions to bone broth and a few other supplements when I was treating with my now "fired doctor" as he labeled me with chronic fatigue. I worked with a functional nutritionist also at that time and she was great in helping me figure a lot of body synthesis, cellular function, biochemical pathways, and others thing out. I think I would have been bedridden if it weren't for her and my kinesiologist.

Anyway the body is complex and doesn't always follow the same pathways each time. I can do glutathione pushes and liposomal glutathione until the cows come home, HOWEVER I cannot do NAC which is a precursor to glutathione and I can only tolerate very, very small amounts of collagen which has glutamine.

I use gabacore for my gaba stores. Straight taurine can be used as well.

It's also incredibly important to stay hydrated!! Please do make sure you increase your water intake!

When they did the TSH at the Emergency Room, they didn't do the Free T3 or T4. I had my TSH checked 1 month ago and it was 2.00 and my Free T3 was 2.19. I have it checked regularly due to Autoimmune thyroid Disease which goes along with Lymes. I think the range for TSH is .04-5.00, but I think some doctors believe 3.00 is too high and is considered hypothyroid.

I knew that for the TSH 4.33 was not normal, but the doctor at Hospital told me was in range but closer to Hypothyroid. It looks like he would have known that tremors and insomnia are symptoms of hypothyroid. All they focused on was insomnia and of course they blamed stress on it. It's so frustrating when you know something else is wrong and no one will listen. It's like talking to a wall. You don't get any answers. I go to my PCP Wed. and I'm going to ask about the TSH test. It's never been that high before.