Anti-Inflammatories?

Well D-limonene is great for heartburn. I've suggested it here and people had good luck with it. The Jarrow brand 1000mg gel caps, 60 for $10 is the best deal on line.

Lol, Astroman.

- chelated MAGNESIUM , or citrate magnesium (this one is very cheap)
"Serum magnesium was found to be inversely correlated with hs-CRP (rs =−0.22, P=0.05) in the entire participants at baseline. Serum hs-CRP declined significantly in both groups as compared with baseline values (median change=0.8 mg/L; PMagnesium= 0.03, PPlacebo < 0.001). Plasma fibrinogen decreased significantly, by 9%, in the magnesium group at the end of week 8 compared to baseline (P=0.001)."
/www.ncbi.nlm.nih.gov/pmc/articles/PMC3685774/

- MELATONIN
"As a consequence, melatonin improves the clinical course of illnesses which have an inflammatory etiology. Moreover, experimental evidence supports its actions as a direct and indirect antioxidant, scavenging free radicals, stimulating antioxidant enzymes, enhancing the activities of other antioxidants or protecting other antioxidant enzymes from oxidative damage. Several encouraging clinical studies suggest that melatonin is a neuroprotective molecule in neurodegenerative disorders where brain oxidative damage has been implicated as a common link. In this review, the authors examine the effect of melatonin on several neurological diseases with inflammatory components, including dementia, Alzheimer disease, Parkinson disease, multiple sclerosis, stroke, and brain ischemia/reperfusion but also in traumatic CNS injuries (traumatic brain and spinal cord injury)"
/www.ncbi.nlm.nih.gov/pubmed/21358973

- OMEGA 3
"Animal experiments and clinical intervention studies indicate that omega-3 fatty acids have anti-inflammatory properties and, therefore, might be useful in the management of inflammatory and autoimmune diseases. Coronary heart disease, major depression, aging and cancer are characterized by an increased level of interleukin 1 (IL-1), a proinflammatory cytokine. Similarly, arthritis, Crohn's disease, ulcerative colitis and lupus erythematosis are autoimmune diseases characterized by a high level of IL-1 and the proinflammatory leukotriene LTB(4) produced by omega-6 fatty acids.
/www.ncbi.nlm.nih.gov/pubmed/12480795

- VITAMIN D3
" Vitamin D inhibition of LPS-induced IL-6 and TNF-α production by BMM from MKP-1(-/-) mice was significantly reduced as compared with wild-type mice. In conclusion, this study identified the upregulation of MKP-1 by vitamin D as a novel pathway by which vitamin D inhibits LPS-induced p38 activation and cytokine production in monocytes/macrophages."
/www.ncbi.nlm.nih.gov/pubmed/22301548

- VITAMIN E
"Acetic acid caused colonic mucosal injury, whereas vitamin E administration suppressed these changes in the AA-induced colitis group (p < 0.001). Administration of AA resulted in increased levels of tumour necrosis factor-α, interleukin-1β, interleukin-6, myeloperoxidase and malondialdehyde, and decreased levels of glutathione and superoxide di****ase; vitamin E reversed these effects (all p < 0.001).
Our study proposes that vitamin E is an effective anti-inflammatory and antioxidant and may be a promising therapeutic option for ulcerative colitis."
/www.ncbi.nlm.nih.gov/pubmed/21933527

- FLAVONOIDS (green/black tea)
"Therefore, from the results of the present preliminary study, it can be concluded that both green and black tea leaves possess a marked anti-inflammatory effect against the denaturation of protein in vitro"
/www.ncbi.nlm.nih.gov/pmc/articles/PMC3401676/

- CURCUMIN
"Curcumin has been demonstrated to be safe in six human trials and has demonstrated anti-inflammatory activity. It may exert its anti-inflammatory activity by inhibition of a number of different molecules that play a role in inflammation."
/www.ncbi.nlm.nih.gov/pubmed/12676044

- RESVERATROL (Polygonum cuspidatum/Japanese Knotweed)
"The PCE-containing resveratrol has a comprehensive suppressive effect on oxidative and inflammatory stress."
www.ncbi.nlm.nih.gov/pubmed/20534755

- ALPHA-LIPOIC ACID
"Administration of irbesartan and/or lipoic acid to patients with the metabolic syndrome improves endothelial function and reduces proinflammatory markers, factors that are implicated in the pathogenesis of atherosclerosis."
/www.ncbi.nlm.nih.gov/pubmed/15655130

- BETA-CAROTENE - Carrots, Pumkins, Sweet potatoes
"beta-Carotene inhibited the expression and production of these inflammatory mediators in both LPS-stimulated RAW264.7 cells and primary macrophages in a dose-dependent fashion as well as in LPS-administrated mice. Furthermore, this compound suppressed NF-kappaB activation and iNOS promoter activity in RAW264.7 cells stimulated with LPS."
/www.ncbi.nlm.nih.gov/pubmed/16155409

there u go, these are all the main ones, i think i covered them all ...

Being the foodie that I am, I try and eat my way to health.

/draxe.com/anti-inflammatory-foods/

Pineapple works super for me. I can't eat it all the time and it is difficult for us just the 2 of us to eat a whole pineapple before it goes to waste, so I supplement with bromelain.

Japanese Knotweed is a great anti-inflammatory.

Glucosamine chondroitin msm are my favs for arthritic inflammation.

I highly suggest Dr. Rawls' book Unlocking Lyme. It is so easy to read and has awesome information in it.

If you can't get his book, he has so much information online for free.

Good points mpost. Appreciate the reminder.

yes Trav, that is why i was saying i very much doubt it's going to work.

on the other hand, you cannot remove invaders without inflammation, you cannot kill them, and it is a known fact that NSAIDs are making our immune systems weaker

/www.ncbi.nlm.nih.gov/pmc/articles/PMC2693360/
a quote from the article: "Inflammation, with its cardinal features: swelling, pain, redness and fever, constitute the primal response to infections, irritations or injuries and is partly mediated by PGE2 production [26]. Thus, administration of ibuprofen during the first stages of inflammation can have repercussions on the immune system by interfering with optimal antibody production.".

so i'd say if you:
a) want to get rid of lyme - you will use some of the new persister treatments with Dapsone, Daptomycin or some other yet undiscovered drugs and would likely leave your immune system do inflammation as much as it wants/needs to and not block it with any anti inflammatory supplements or drugs and hope the antipersister drugs destroy a huge number of bacteria and your immune system mounts some oxidative stress good enough to clean the rest ... OR....

b) you want to reach a balance with the lyme bacteria - you reduce the inflammation by any means possible while at the same time take some antibacterial herbs.... and you are prepared to do that indefinitely, or at least until the people that try a) get really really good results ;)

Seriously , TB was thought to be incurable and now it is, so chronic lyme will be too ... and who knows, maybe we can take with us and cure 20% of the MS patients as well .... what a joyful thought....

mpost said...
yes Trav, that is why i was saying i very much doubt it's going to work.

on the other hand, you cannot remove invaders without inflammation, you cannot kill them, and it is a known fact that NSAIDs are making our immune systems weaker

/www.ncbi.nlm.nih.gov/pmc/articles/PMC2693360/
a quote from the article: "Inflammation, with its cardinal features: swelling, pain, redness and fever, constitute the primal response to infections, irritations or injuries and is partly mediated by PGE2 production [26]. Thus, administrations of ibuprofen during the first stages of inflammation can have repercussions on the immune system by interfering with optimal antibody production.".

so i'd say if you:
a) want to get rid of lyme - you will use some of the new persister treatments with Dapsone, Daptomycin or some other yet undiscovered drugs and would likely leave your immune system do inflammation as much as it wants/needs to and not block it with any anti inflammatory supplements or drugs and hope the antipersister drugs destroy a huge number of bacteria and your immune system mounts some oxidative stress good enough to clean the rest ... OR....

b) you want to reach a balance with the lyme bacteria - you reduce the inflammation by any means possible while at the same time take some antibacterial herbs.... and you are prepared to do that indefinitely, or at least until the people that try a) get really really good results ;)

Seriously , TB was thought to be incurable and now it is, so chronic lyme will be too ... and who knows, maybe we can take with us and cure 20% of the MS patients as well .... what a joyful thought....

maybe its this inflammation response with the biofilm slicing ability of metlittin that makes bee venom so effective ....the in vivo response to both dapsone and dapto on ln have been minimal at best ...folate is needed by bugs and us.charles mraz and pat wagner have been curing ms for 30yrs

For anti-inflammation I cut out all gluten/sugar and I take:

-Glucosamine chondroitin
-Wobynzyme PS (GREAT!)
-Turmeric
-Stephania Root
-Spriulina
-Dandelion tea

All of these help so much that I can see the difference in my face. I used to have a lot of edema around eyes - all gone.

So Peteza, do you like the Rawls book? LOL! I'll have to check it out.

Trav:
I hope I didn't come too strong with this as an anti-pharma. I simply suggested what worked for me and I gave some suggestions. I'm sorry you are dealing with back pain. I know it's terrible! Once or 2x per year I have flair-ups from herniated disks and I take Gabapentin (1-3 pills per year). Plus I take levothyroxine. But for pain that is not nerve pain, I found the above to work well and I was able to avoid NSAIDs and Tylenol.

I don't know if KB tried eg Japanese Knotweed, which is safer than NSAIDs or other pain drugs. JN did wonders for my sister, who was out of work for 1 yr due to an injury on the job. JN (3x/day) and Propolis helped her get off oxycodone and other powerful drugs. Sometimes we just don't know of better options until we find out from others, as I found out from here on the forum and I was able to pass the info to my sister and not only. BTW, my sister is a RN and she was clueless about herbs. Now she makes her own tinctures, thanks to you and others here that helped me make mine

JN=Japanese Knotweed LOL I meant to write JK

It sounds like you are in need of a good chiropractor to adjust you, I'm so sorry you are in so much pain! My problem is lower back pain, but only a couple of times per year, it used to be much worse, but I guess it is healing. I can use a belt around my waist, which helps a lot, so I hardly ever need meds now. It is usually after my kids play with my belt and misplace it that I can't find it right when I need it, and after a few days of walking like Frankenstein, a give in and I take a gabapentin for nerve pain. The fun of having kids, they get into everything!

Oh, and about my sister, not only my sister uses JK, but her entire section! She got them hooked! They love it! She works in the psych unit and the patients get violent sometimes, and pretty much everyone in the section gets hurt at some point and needs pain meds. She carries JK in her pocket LOL