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methylation issues and need help

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Posted 4/14/2017 2:35 PM (GMT 0)
Is there someone on this site that can help me figure out my 23andme results? What info will you need? I am compound heterozygous for A1209c and c677t. My doc has me taking B Specific which includesB1, B2, niacin, Pantothenic Acid, B6, Biotin, ALA, L-Lysine HCL, and Pantethine. This doesn't seem right. I also have CBS variants. Thanks for any help.

Patty
Posted 4/14/2017 3:21 PM (GMT 0)
Patty,
I don't know enough about this to be of help, but I'll help you keep it bumped up until someone that does understand this can help you!
Posted 4/14/2017 3:24 PM (GMT 0)
Patty, did you try Genetic Genie for interpreting your results?
Posted 4/14/2017 3:38 PM (GMT 0)
Thanks for the replies. PeteZa, I will look up Genetic Genie. Right now my anxiety and brain fog are so bad I am not sure I can handle that site right now.

Patty
Posted 4/14/2017 3:46 PM (GMT 0)

summer16 said...
Thanks for the replies. PeteZa, I will look up Genetic Genie. Right now my anxiety and brain fog are so bad I am not sure I can handle that site right now.

Patty

I think all you do is download the file from your computer and they give you results. They ask for a donation, but I don't think there is a cost. Anyway the last time I helped someone with this, that is the way it was. Hopefully it hasn't changed.

Sorry your anxiety and brain fog are so bad now..... Time to rest and drink tea and baby yourself.
Posted 4/14/2017 6:28 PM (GMT 0)
bump for more views.
Posted 4/14/2017 11:32 PM (GMT 0)
Hi summer16

Can you post your full results here?

We went through the methylation thing all last year with the information gleaned from the Phoenix Rising forum.

I notice B12 isn't in your B-group list, and including ALA isn't usually highly recommended. These two things might be a reason you might not be feeling quite right on it. You can get very, very sick from supplementing folates without having enough B12 in your system.

And that stuff (B specific) looks expensive (from a quick google search). You can get better multi-Bs for less. Jarrow B-right is the usual starting point: it's cheap , lower dose (so no risk of overdrive), and has active forms of the B vitamins.

On the other hand, if you're doing well and just a bit worried, then maybe it's not an issue.

The CBS variants have a lot of misinformation associated with them. Yasko says it's serious, others say she's wrong. We don't seem to be affected so I haven't had to tiptoe through that minefield.

I can tell you what we do, if that helps.
Posted 4/15/2017 3:05 AM (GMT 0)
Ccc- better, thank you. I will get my results to you tomorrow. I was taking sl b12 but the doctor changed the B's 6 weeks ago. Thanks for the tip about where to get the less expensive version.

Patty
Posted 4/15/2017 4:26 AM (GMT 0)
Hi summer16 -

If you already know you are heterozygous for A1209c and c677t, seems like you've already had your 23andme DNA data interpreted. I think this has changed with the new "laws" but they were previously prevented from interpreting any data and so people would have other websites take the mounds of data (hundreds of thousands of synapse codes that they would provide in a .txt file) to get interpretations and results like the A1209c and c677t, etc…

Anyway, being heterozygous for A1209c and c677t is VERY common with us Lymees (and there's probably some connection between those DNA mutations and being more susceptible to the Lyme symptoms (as I think most people have Lyme but aren't symptomatic), but that's a different conversation).

appx 30% reduced function
"Heterozygous" means you have an approximately 30% reduced function of those genes that control detoxing and methylation (which is the production and processing of chemicals/hormones and other stuff your body gets from foods and hormones and also produces). If you were homozygous for the A1209c and c677t synapses, you would have roughly 60% less function.

Here's the kicker… There are MANY MANY MANY other DNA mutation possibilities than just those two, but they are the two most common. However, it's only a teeny tiny part of the full picture and that's why I think that info is only a little helpful. I think what helps us more is just knowing you have some detoxing blocks and that you might need to do some trial-and-error to figure out what works for you and helps you process your treatment better and heal more holistically.

Specialist
Is your "doc" a Lyme specialist? Even Lyme specialists aren't generally well-versed in methylation issues. They all seem to have taken the same 60-minute seminar and none of them fully understand it (including mine, and she's brilliant and so is the Lyme nurse). I think you'll have better luck with an ND but the more I read about methylation problems and the DNA mutations we are learning about, the more complicated the solutions sound.

B12
ccc-better mentioned B12 was missing and I agree. And you'll have to also figure out if you need the methyl version, the hydroxy version or something else. I think it's hydroxy but please double-check me. Also, you probably shouldn't be taking B6 because you might not be able to process it, some people even have adverse reactions on it. I'm really sorry but I can't remember why I know this - it might be that I discovered more methylation mutations than the two you mentioned…

Your supps -
niacin helps dilate your blood vessels, might help with tinnitus
L-Lysine is good for reducing viral loads
HCL is hydrochloric acid - helpful for digestion but take it with food,
I'm not sure about B1, B2, Pantothenic Acid, Biotin, ALA or Pantethine - sorry

You might find good info at mthfr.net - might take you awhile to get though it. There is also a specialist in autism - Amy Yasko and her website has very good info, too. I think it's free to run your data through - she sells supplements but you don't have to buy anything.

I LOVE the site LiveWello.com for hundreds of programs you can run your 23andme DNA data through… almost too many - it can be confusing. I believe it's $50 for unlimited programs.
Posted 4/15/2017 3:47 PM (GMT 0)
Methalation is confusing stuff.



This has lots of info, but its arranged poorly. It does have some plan of action.

heartfixer.com/AMRI-Nutrigenomics.htm

There are Drs trained for this by Dr Ben Lynch , here:

/mthfrsupport.com/find-a-practitioner/

I tried addressing some of this, without much good. But its worth a try. Problem is, the more you have, obviously harder to find positive results.

Yasko has a lot of info, but my experience in the past is its all over the place, no order. she needs to re-organize everything of hers on-line. I gave up.

My rant: There is no SIMPLE site with a chart for what supps to take for which gene defects one has. Why not? Is the problem is being the people into this are the "mad scientist" types who cant tie their shoe laces? LOL

Charts are easy, we need a chart, I suppose a big flow chart, of what comes first. Ancient Basic C programming language is nothing more than a flow chart of direction, easy, and simple.
Posted 4/22/2017 10:06 PM (GMT 0)
Maybe focus on anything with +/+ or +/- and list that here.

We can then start looking.

For example, if you have any COMT issues, this thread might be helpful:
http://forums.phoenixrising.me/index.php?threads/interesting-comt-variations.24672/

CBS:
http://forums.phoenixrising.me/index.php?threads/interesting-cbs-variations.24492/

MTHFR:
http://forums.phoenixrising.me/index.php?threads/interesting-mthfr-variations.24543/

I am not the author of those posts, but the lady who is, is the goto person on this stuff in my opinion.

Post Edited (ccc-better) : 4/22/2017 4:10:46 PM (GMT-6)

Posted 4/29/2017 2:12 AM (GMT 0)
I am so sorry it took so long to get back to you guys. Anxiety is killing me, unfortunately.

Astroman, this stuff is very confusing especially when the brain cannot comprehend much info. Addressing these issues hasn't worked out for me.

Pirouette and ccc-better, my LLMD is an ILADS doctor and has no understanding of methylation problems. I have been seeing a functional chiropractor and did have the 23andme test done. He has been working on my issues for a few months but I seem to react horribly with his treatment. He was working on the pathways one at a time but with bad results for me. When I suggested to go slower on the supplements he had a meltdown over the phone. Not cool. For awhile I was cutting the supplements to thirds but felt guilty so I upped my dosages faster than I should have. Shame on me....I know better.

At one point I was alternating B12 with hydroxocabalamin and methylcobalamin along with taking B6. I have no idea why he changed to the B-Specific. I am supposed to see him in another 1 1/2 weeks but may stop treatment altogether. I am very disappointed especially with the high amount of money that has been paid out. Right now I am not taking any B vitamins until I get this figured out.

Pirouette, I have a 50% reduction due to other mtr snp's.

PeteZa, the 23andme results were interpreted but I still can't make heads or tail of it and also too afraid I might get it wrong. It seems everything I try to do just backfires. And, believe it or not, I don't know how to download files.

Here are some of my snp's: I know I am working at 70% for gluten intolerance and 50% for lactose intolerance.

ABP1: 1 variant on ABP1 (rs 1049793), working at 90%

HNMT: 1 variant on rs1020678, 1 variant on rs134992, 2 on rs1455164, 2 on rs1455164, 1 on rs1580111, 1 on rs3100701, 2 on rs003891, histamine clearing 77%

ACAT1-02: 1 variant on rs3741049 which is the most significant snp

SLC16A1: 2 variants on rs7169, 1 variant on rs3849174m rs12028967 andrs4301682

NDUFS7: 2 variants on rs1142530, rs7258846 and rs809359 and 1 on rs2332496, working at 13%

SOD: 1 variant on rs2758331 and rs4880, working at 70% (detox ability)

Glutathione: 2 variants on SHMT2 (rs34095989) and 1 onCTH (rs1021737), states Glycine/SHMT is at 0%

FOLR1 (adult) (rs2071010) no variants for folate receptor sites

DHFR (rs1643649) 2 variants, varians here will indicate the need for methyl folate and PRO NADH. BHr support and glutathione support may also be needed. SO my DHRF is at 0%

SHMT2: 2 variants (rs34095090)

MTHFR A1298C (rs1801131) 1 variant

MTHFR c677t (rs1801133) 1 variant " It is currently theorized that the c677t impacts the methionine cycle more significantly while the A1298 impacts the BH4 cycle. If this theory is correct, those with c677 would need more support in reducing Homocysteine while A1298c may need more support with creating BH4 and preventing NOS uncoupling. Nonetheless, there is usually a need for folate with these variants. However, to be sure, ehcking the urine organic acids can confirm, and can also be used as a measure when adequate levels aare reached when supplementing. With two MTHFR variants, there is a good chance of need for folate, but using the urine organic acids test to vserify may be helpful, as some people can compensate. If this is two copies of c677t, there may be more need for methylation support, and if both copies are A1298c, there may be more need for BH4 support, and if one of each, both pathways may need more support."

MTR A2756G (rs1805087) 1 variant

MTRR A66G (b12) (rs1801394) 1 variant both MtR and MTRR working at 50%

GIF (TCN3) (rs558660) 1 variant

TCN1 (rs526934a0 1 variant

TCN2 c766g (rs1801198) 1 variant

BHMT 1 variant

BHMT R239Q 1 variant

BHMt-02 1 variant

BHMT-08 1 variant

CBS A13637G 1 variant

CBS C19150T 1 variant

CBS c699t 1 variant

CtH 1 variant

BHMT-08 1 variants

COMT H62H (MIR4761) 2 variants

COMT v158M (MIRA761) 2 variants

GAD1 (rs2241165) 2 variants

GAD1 (rs12185692) 1 variant

GAD1 (rs3828275) 2 variants

DAOA (rs2391191) 2 variants

NOS2 (rs2274894) 2 variants

NOS2 (rs2248814) 2 variants

NOS3 (rs1800779) 1 variant

NOS3 (rs3918188) 1 variant

NOS3 D298e (rs1800783) 1 variant NOS production 44%

OTC (rs12557315) 2 variants

ASL (rs313830) 2 variants

ASL (rs313829) 2 variants

Well, there you have it. At the end of the report it is stated tha tmy findings may suggests that lowered energy production in the Krebs Cycle and may be a factor to chronic lyme. and maybe nutritional intervention of carnitine, choline, NADG (whatever that is), CoQ10 and pantethenese might be useful??

OK, I am dying. That's all there is to it!!!!!! Gosh, does anybody have a clue? All I want to know is what B vitamins to take for now.

For anyone who has read all this thank you very much.

Patty xo

Post Edited (summer16) : 4/28/2017 8:18:35 PM (GMT-6)

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