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Tingling has been worse

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Posted 4/30/2017 12:31 PM (GMT 0)
Hello,

I used to take 50mg B6 every day in the pyridoxine hydrochloride form. It ran out and didn’t repurchase for a while and I noticed that I have been more constipated than usual. As B6 helps with magnesium absorption, I thought my body was missing B6 so bought some but now the P5P formula. Last night I took I capsule (50mg P5P that has an actual B6 content of 40mg) and within one hour I had tingling in my right calf. This got worse during the night and also had it in the left calf and both arms. Also needle like pain and sometimes like warm water running down on the calves. Mostly I have been having the pins and tingling on my hands and calves/feet but sometimes in the collar bone area and head too. Sometimes I have something like a small electric shock pain too.

I am not sure if it has anything to do with taking this new B6 as 40 mg is really not much and I had similar symptoms before thinking these were due to Lyme and co. And never had any adverse reaction to the other B6 I used to take. However, these pins and tingling feel different. Stronger, burns more and more persistent although I haven’t been having it continuously. It’s been stopping for a little bit, like for a few minutes, then starts again. I haven't changed anything else in my diet/supplements.

Of course I’m not going to take it today. If the pain goes away, I will try again, in a lower dose, in a week or so to see if this was the culprit.

Anybody had unusual stronger pins and tingling shortly after taking P5P?

Thank you!
Posted 4/30/2017 12:45 PM (GMT 0)
Could it be that you don't need to supplement with that high of a dose? Do you have tests showing that you are particularly low in B6?

Those are symptoms of B6 toxicity, even though you aren't taking the upper limits like they talk about here:

" Although vitamin B6 is a water-soluble vitamin and is excreted in the urine, long-term supplementation with very high doses of pyridoxine may result in painful neurological symptoms known as sensory neuropathy. Symptoms include pain and numbness of the extremities and in severe cases, difficulty walking. Sensory neuropathy typically develops at doses of pyridoxine in excess of 1,000 mg per day. However, there have been a few case reports of individuals who developed sensory neuropathies at doses of less than 500 mg daily over a period of months. Yet, none of the studies in which an objective neurological examination was performed reported evidence of sensory nerve damage at intakes below 200 mg pyridoxine daily (90)."

lpi.oregonstate.edu/mic/vitamins/vitamin-B6
Posted 4/30/2017 1:32 PM (GMT 0)
I never had a blood test but always found that I don’t absorb magnesium well without a daily dose 50mg. I stopped B6 a few times over the years and always became more constipated.
I found an interesting article. According to this the B6 blood test can be confusing: www.easy-immune-health.com/vitamin-b6-toxicity.html


I haven’t been taking B6 for about 2 weeks now and yesterday took only 50mg P5P. I doubt that can cause toxicity. I was rather thinking that maybe people with Lyme and co are more sensitive to the P5P form of B6 than the pyridoxine hydrochloride.

It is hard for me to decide if it has anything to do with my new B6 or if it is a random stronger Lyme and co flair-up so thought I would ask if anybody takes P5P.
Posted 4/30/2017 1:47 PM (GMT 0)
It's a good question, and my next suggestion would have been it's the change of brands or type of B6 possibly.

From the article you linked to:
"This is because the vitamins build up in the bloodstream, where they are measured, but the vitamins can't get into the cells where they are needed."

This is what I have going on with a few things!
Posted 4/30/2017 2:04 PM (GMT 0)
Yes, that is so annoying. They tested my B12 three years ago and it was high (well above the upper reference limit) without any supplements. So all this time I have been resting assured that I don’t need to take B12. But now I’m thinking that might not be the case.
Posted 4/30/2017 2:11 PM (GMT 0)
You might want to try a small dose for a while to see if it helps any. Do you know if you have any of the gene mutations we talk about(MTHFR)? If so, you may need a different type of B-12 as well. I used the cyano B-12 and it made me more tired, but once I switched over to the methyl B-12, it has helped tremendously.

Some still have trouble with the methyl B-12, so they take the hydroxy type of B-12.
Posted 4/30/2017 5:07 PM (GMT 0)
I don’t know if I have the MTHFR gene mutation.

Some time ago I was advised that if I ever need to supplement B12, go for methylcobalamin but I haven’t heard of the hydroxy type yet. Thanks for the info.
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