Literature Citations Needed - Doxycycline Failure to Eradicate Bb - Updated With Citations!

Doxy creates 200% more cysts according to sapi

/www.ncbi.nlm.nih.gov/pmc/articles/PMC3132871/

Weild the sword of truth mustardseed! (if we just had that much faith)

Doxy did keep me going well for many years....I just had to take it every 3-4 months. So it does have value, it needs more to go with it, though.

Going great!

I haven't posted this anywhere yet, but I did some reading yesterday and acquired links to a few studies that show Borrelia persistance. Anyone can feel free to copy/paste as needed:

Doxycycline reduced spirochetal structures about 90%, but increased the number of round body forms about two fold:
/www.ncbi.nlm.nih.gov/pmc/articles/PMC3132871/

Portions of B. burgdorferi organisms may be tolerant to doxycycline following their entry into a state of dormancy:
aac.asm.org/content/59/10/6288.full

30 days of doxycycline diminished but failed to eradicate persistent Borrelia infection in dogs. Dogs that were kept in isolation for 6 months after antibiotic treatment showed increasing antibody levels, in response to proliferation of the surviving pools of spirochetes:
jcm.asm.org/content/35/1/111.full.pdf

Borrelia DNA/RNA detected after treatment with 30 days IV ceftriaxone followed by 60 days doxycycline in non-human primates:
journals.plos.org/plosone/article?id=10.1371/journal.pone.0029914

Borrelia DNA found both after 15 days of IV ceftriaxone and 30 days oral doxycycline:
www.jci.org/articles/view/58813

Mitomycin C in combination with doxycycline and cefuroxime did not eradicate Borrelia, however daptomycin with doxycycline and cefuroxime did:
/www.ncbi.nlm.nih.gov/pmc/articles/PMC4748043/

Doxycycline cannot eradicate Borrelia persisters, some other medications do a better job, but still cannot provide total eradication:
www.mdpi.com/2079-6382/4/3/397/htm

Doxycycline creates drug tolerant persister bacteria:
aac.asm.org/content/59/8/4616.full

DNA sequencing of spirochetes which survive doxycycline therapy:
/www.researchgate.net/profile/Shuo_Zhang41/publication/282345075_Persister_mechanisms_in_Borrelia_burgdorferi_Implications_for_improved_intervention/links/5630018c08aefac54d8f08dd.pdf

PCR positive for Borrelia after 30 days IV ceftriaxone:
journals.plos.org/plosone/article?id=10.1371/journal.pone.0086907

IV ceftriaxone plus anti-TNF-alpha does not eradicate spirochetes:
/www.ncbi.nlm.nih.gov/pubmed/17436229

Post Edited (Mustard Seed) : 5/23/2017 11:23:57 AM (GMT-6)

Awesome thanks Traveler! I'll bookmark them when I get back on the laptop.

Trav, that 3rd link you posted, I came across randomly and had posted it in that thread yesterday.
That is one fantastic piece of literature!

Absolutely essential reading for anyone following IDSA Guidelines.

Wow! Fantastic writing in that thread Mustard Seed. Great job. I actually am really glad I read that because your nemesis said his knee swelled up and clicked for awhile but now it is better. So good to hear because the same thing happened with me and I fear this knee will never recover :/

I was once an avid MTBr too. Raced Cat 1 on a carbon fiber stump jumper 29" hardtail. Was shooting for my pro card in triathlon when I got sick