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Posted 5/25/2020 1:33 PM (GMT 0)
I want to stop my treatment of disulfiram because I think it’s causing me severe depression and anxiety.I am so depressed right now I am scared.She says I am progressing on it and wants me to continue for a few more weeks.i already don’t have much of an appetite and I am not sleeping at night.I can’t seem to shake this doom and gloom.If you have had this feeling in the past what did you do to pull yourself up.Thanks
Posted 5/25/2020 1:49 PM (GMT 0)
Sorry you are struggling. If it were me I would push through the treatment in order to kill everything off. Or do you think taking a break is ok a,d then see how you feel? Are you detoxing enough? Maybe your body is full of toxins, I know I have felt awful mentally when I don't detox enough. Have you tried anything natural for sleep? Valerian can help. I'm really sorry you are having a hard time. I know a lot of people feel this way but then end up getting better amd are so glad they pushed through.
Posted 5/25/2020 1:59 PM (GMT 0)
Hi yes I do use the sauna and do epsom salt foot baths.I have to push myself to eat and take my meds now and to drink water.I let the pandemic scared me and I spiraled.Now I can tell my husband is a little depress.I am trying so hard.Where can I get Valerian?Thanks

CalmLittleBuddha said...
Sorry you are struggling. If it were me I would push through the treatment in order to kill everything off. Or do you think taking a break is ok a,d then see how you feel? Are you detoxing enough? Maybe your body is full of toxins, I know I have felt awful mentally when I don't detox enough. Have you tried anything natural for sleep? Valerian can help. I'm really sorry you are having a hard time. I know a lot of people feel this way but then end up getting better amd are so glad they pushed through.

Posted 5/25/2020 2:30 PM (GMT 0)
Most of the people I know who have stopped taking disulfiram have done so because of crippling psych symptoms. Only you can decide how long you can handle it and if the possible payoff is worthwhile. Psych symptoms are just as dangerous as other symptoms! I know you want guidance, but it's one of those situations in which no one can tell you what's tolerable except for you. So sorry you are dealing with this!
Posted 5/25/2020 2:40 PM (GMT 0)
What kind of symptoms do they describe as psych symptoms?I am severely depressed like I am paralyzed.I feel so bad for my husband and 7 year old because I am emotionaless.

saraeli said...
Most of the people I know who have stopped taking disulfiram have done so because of crippling psych symptoms. Only you can decide how long you can handle it and if the possible payoff is worthwhile. Psych symptoms are just as dangerous as other symptoms! I know you want guidance, but it's one of those situations in which no one can tell you what's tolerable except for you. So sorry you are dealing with this!

Posted 5/25/2020 5:01 PM (GMT 0)
You could try taking some Vitamin C to aid dopamine conversion into norepinephrine.

Vitamin B12 might help too.

Wishing you the best.
Posted 5/25/2020 5:09 PM (GMT 0)
FM, You can get Valerie. (Amantillia) off the nutriamedix, it's not expensive. We all understand how you feel when you say that you feel sorry for your husband and son, chonic illness for sure affects our families too, it's so hard. And this pandemic is defiantly making things worse for people like us. I am wondering if you would feel better if you got some nutrients amd fluids in you. Can you take a few days for yourself and try to not watch the news and recenter your body, by eating healthy foods amd maybe getting some sun. I think what you are feeling might be Depersonalization, your body knows that you are over stressed and it gose into flight or fight mode, it's really scary but your body is trying to protect its self.
Posted 5/25/2020 5:34 PM (GMT 0)
The problem is that disulfiram inhibits dopamine beta hydroxylase, which means that the dopamine can’t be converted to norepinephrine, and builds up causing a type of psychosis.

There’s also evidence that it inhibits the breakdown of caffeine.

Caffeine and dopamine are both catecholamines.

Since COMT is necessary for methylating catecholamines, it seems logical to me that those w genetic COMT activity deficiencies are most at Risk as their catecholamine removal is already hampered. This is a real thing. I have a severe COMT deficiency and cannot handle caffeine or alcohol or anything that increases dopamine.



In Dirty Genes Ben Lynch has a few recommendations. The two that stick out in this situation are phosphadityl serine to calm you down and SAMe to help methylate those neurotransmitters. But watch out w SAMe if you overmethylate you could be up worse off.

Also taurine and lots of magnesium

Post Edited (dcd2103) : 5/25/2020 11:38:09 AM (GMT-6)

Posted 5/25/2020 6:05 PM (GMT 0)
Psych symptoms: depression, anxiety, depersonalization, psychosis, etc.
Posted 5/27/2020 10:23 PM (GMT 0)
I just went through that yes it sucks but i felt better after 11 days off of it i have a Drs appointment next tuesday with my llmd i would like ro continue on a lower and slower dose like maby 62.5 every other day and carefully go up it was helping but im going ro ask Dr for abx combo to go along
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