potsnpans said...
How do you know that the concentration of carvacrol can be high enough in cistus tea? ..also wondering what happens when carvacrol is ingested.. how much of it (if any) makes its way into the blood?
I dont know the concentration of Carvacrol , what i know are the results it has on my infection and on others infections from the reports and testimonies i have read and compare all that to the scientific studies made about
it that try to explain the why's and how's of that same results and i have finally found it.
In terms of blood concentrations there are very few, if any studies, on human carvacrol absorption, but
there are many studies in carvacrol absorption to the blood in animals. I found this, i have cut some more relevant conclusions from the texto. To read the complete text follow the link below.
Quote:
"3.1 | Pharmacokinetics—absorption, distribution,
metabolism, and excretion of CV
According to studies performed in rabbits, CV is slowly absorbed in the
intestine after oral administration (1.5 g), with more than 30% remaining
in the gastrointestinal tract and about
25% of the total dose excreted in
urine 22 hr later (Suntres et al., 2015). A further study, where different
doses of CV derived from sesame oil were orally administered to rats
(500 mg) and rabbits (1,500 and 5,000 mg), showed this compound to
be mainly distributed in the stomach, intestines, and urine, with small
amounts in the lung, liver, and muscle tissues (Schroder & Vollmer,
1932). In pigs, intestinal delivery of CV was greatly improved by
alginate–whey protein microcapsules, that is, 250 and 800 μm in diameter, containing 72 and 76 g/kg of CV, respectively (Q. Wang, Gong,
Huang, Yu, & Xue, 2009). Results showed over 95% of unencapsulated
CV was absorbed or metabolized in the stomach and the duodenum,
whereas microcapsules completely released the compound in the intestinal tract; larger microcapsules, in particular, showed a better recovery
in the small intestine than smaller ones (Q. Wang et al., 2009). Therefore,
orally ingested unencapsulated CV was mostly absorbed or metabolized
intheuppergastrointestinaltractofpigs,whereasalginate–wheyprotein
microcapsuleseffectivelyminimizedthe absorptionofCV inthe stomach
and proximal intestine and increased the percentage of CV delivered to
the distal small intestine (Zhang et al., 2016).
These
authors also showed that CV (1 mmol/kg) is excreted in urine, as such
or as its glucuronide and sulphate conjugates in Albino rats (Austgulen
et al., 1987); Through gastric fermentation simulation
experiments in piglets, 29% degradation of CV occurred in the cecum,
and not in the jejunum, but when the animals were treated with oral
doses of 13.0, 13.2, 12.5, and 12.7 mg/kg of body weight of the compound, they showed a half‐life between 1.84 and 2.05 hr throughout
the digestive tract (Michiels et al., 2008). These results suggested an
almost complete absorption of CV in the stomach and the proximal
small intestine. Plasma levels peaked at 1.39 hr followed by a peak in
urine (time of maximum response = 2 hr; Michiels et al., 2008). The
cumulative absorption of CV and TH in the proximal small intestine
was higher than 90%, without being affected by dose and formulation
administered to piglets (Michiels et al., 2010).
To date, no in human evidences are available; thus interspecies
differences in bioavailability, metabolism, and distribution should be
taken into account.
Research link:
https://www.researchgate.net/publication/324942601_carvacrol_and_human_health_a_comprehensive_reviewSo the best we have are animal studies, but on these we can ser that carvavrol is absorbed trought the intestines. This means like this study concludes, that we must calculate the differences on animal/human metabolism/distribuition. This could translate in to only small ammounts of carvacrol absorbed into human blood stream
I also found in another study that micro ammounts of carvacrol in humans could imhibit câncer cells. So even if the concentration absorbed is low, the effect can be surprising. Great quantities of a substance do not translate proportional effect. Sometimes less can mean more.
What i know, is what i saw in me and on several reports like i already mentioned. Carvavrol is only a partial explanation of that same results.
All the best
Post Edited (isitlyme) : 11/17/2020 12:50:23 AM (GMT-7)