MargaritaLyme said...
I disagree that individuals lack the ability to constructively debate unless this is an example..
i'm not sure i am understanding your point here Margarita?
MargaritaLyme said...
...I also fail to see where explaining away effects of one treatment as placebo effect couldn’t easily be said about all Lyme treatments.
Actually, i pointed to more than the placebo effect as reasons for scepticism
but, regarding not being able to see why one couldn't explain away all Lyme treatments as placebo:
A pragmatic approach would be to look at all the evidence for such treatments and how consistent it is
So, if we were to take antibiotic-based treatments as an example
• There is a huge amount of basic biology research revealing the similarities and differences between borrelia and other well studied bacteria that share some of the same genes and metabolism, which help us understand which drugs might be effective against them and why
• And then there are cell culture in-vitro trails showing these drugs to be active against Lyme and associated infections in-vitro
• There are then animal trials also showing efficacy of abx in other mammals which support that these drugs may be useful in humans
• There are then a number of large-scale clinical trials of human lyme patients showing efficacy of abx
So, looking at the scientific literature alone - there is a large, consistent and multi-layered body of scientific knowledge supporting the effectiveness of various antibiotics against borrelia - each layer consistent with the layer below it.
As well as being compelling in their own right, when these lines of evidence are consistent with each other like this, it gives greater confidence that the effectiveness in humans is real – not placebo.
Then, in addition to the scientific trials, we also have the published work of many LLMD’s who are medically trained, have each treated thousands of patients and and support the use of antibiotics in treatment of lyme disease.
And, in addition to that we have the anecdotal accounts from various sources – such as the members here - and on other lyme forums
In contrast, the evidence supporting “magnet therapy” appears to rely solely on this last type of anecdotal report. And even here the numbers that report positive results are small.
The members here reading such small numbers of N=1 anecdotal reports have no way of knowing if, for example:
• These people would have improved anyway,
• or if the reported improvements were due to placebo effects
• or the people reporting them were doing other therapies at the same time that they neglected to mention,
• or for example a person even took 3 months of antibiotics, or some other treatment prior to trying magnets
such is the difficulty with anecdotal reports.
and supporting evidence, from basic biology, to cell culture trials, to animal trials, to human trials is entirely lacking.
That is not to say that antibiotics are a perfect treatment. We know they are not. The same scientific body of knowledge shows that bacterial persistence after abx is a real phenomenon, and is now uncovering the mechanisms by which this happens.
I just use abx as an example to show the difference between something where there is a great deal of consistent evidence supporting - and something where none of that exists and yet practitioners make a living from it nonetheless.
Anyone interested in a balanced evaluation of their options for treating Lyme disease really ought to be able see that there certainly is a real objective difference between these treatment options in terms of evidence.
to place all Lyme treatments on a kind of level pegging, based on the fact that one hears anecdotal accounts of success and failure on all of them is missing a big part of the picture.
Pragmatically - most humans will be most likely to be helped most by the things that have helped the most other humans.
So, I would urge people reading this to take a pragmatic approach – weigh all the evidence – work from the top down and resist the urge to dive into fringe therapies on the basis of anecdotal reports alone - or charismatic practitioners or the things you react to positively emotionally – in fact be cautious of the things you would like to be true, as that is often simply not how the world is.
again, all the best!
Post Edited (Garzie) : 1/1/2023 3:10:38 PM (GMT-8)