I have been taking the serrapeptase, nattokinase, lumbrokinase as well as a potent digestive enzyme for months now and I definitely see a difference.
I just want to mention tho that for the ones that are really quite ill, when you begin to take the enzymes I think they could make you sick with the toxins that are released from the biofilms, similar to a herx so you may have to go slow with the enzymes.
Also, just a thought - the nattokinase has the effect of making the blood thinner so if that is an issue for you, you might want to consider that as well.