should I switch to different combo of antibiotics?

So I've been on Biaxin, Ceftin, Amanadine(3wks of months), then flagyl and amandaine 1wk each month, my doctor said he could try me on minocycline + augmentin +amandine, still  cycled with the flagyl. However he also said he does not think this is going to make much of a difference. And that it's up to me if I want to switch? I've been on the same meds for about  8 months, still having very harsh and more frequent flare ups, lasting weeks and months at a time. I'm also on iv rocephin.

So the question is I'd be going from Biaxin ( macrolid), ceftin(cephalosporin) to a Penicillin (augmentin) and a tetracyline (mino) anyone been on a similar combo and which did one work better than the other. I'd be switching different classes of meds so I'm thinking maybe they will work a little different for me.

Another concern I have is Biaxin is supposed to be one of the best for lyme, so if I go off it will it still have any effect if I go back on?

 

What does your gut tell you to do? It's possible that the bacteria are resistant to the abx you've been on for a while, as they're known to do this, though I think people usually switch things up when they feel like they've hit a plateau. If you feel like it's working, it might not be worth the risk of "losing" its effectiveness if you want to go back to it.

Just from my personal experience...I'd been on some combination of ceftin, doxy, tindamax or plaquenil, and azithro for a good 6 months to a year, and then I switched to minocycline and boy did that pack a punch! I was only on it for about a month, before my doctor and I decided it was obvious it was making me too sick to continue, it was just the strongest herx of my life and I guess I wasn't ready for it - it was the only thing that finally boosted my CD57 up to almost normal range, and its gone down since then. My guess was that it was either because I'd never been exposed to mino (so the bacteria had no way of protecting itself), or that it went straight to the infection in the brain (it crosses the blood brain barrier, I think) whereas some of the other abx may not get there.