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Igenex lab results

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Posted 9/7/2012 10:50 PM (GMT 0)
Hi Darlings, FINALLY got my igenex lab results. I've read a bunch of great links about what the bands mean, but can someone tell me what this means TO ME? LOL!!!! My LLMD and I will have a call next week and I KNOW you aren't doctors, but I'm eager to understand.

I was sick several years ago ... really sick. Never been right since. Was tick bitten this Spring and had bullseye so found an LLMD treating me for active infection, believing I've had this for a long time.

LYME IgM Western Blot

Bands not listed here were all negative.
28 kDa +
**31 kDa. ++
**34 kDa. ++
**44 kDa. +

LYME IgG Western Blot
**39 kDa. +
**41 kDa. +++


Thanks so much for looking at this.
Posted 9/8/2012 2:12 PM (GMT 0)
Igenex Western Blot Break Down by band

9 cross-reactive for Borrellia
12 specific for Bb
18 highly specific to Lyme (Many LLMD's say if this band alone is positive, you have lyme - see link above)
20 cross-reactive for Borrellia
21 unknown
22 specific for Bb, probably really the 23/25 band
23-25 outer surface protein C (OspC), specific for Bb
28 unknown
30 unknown; probably an outer surface protein; common in European and
one California strain - Has cross-reactivity with several different types of viruses
31 outer surface protein A (OspA), specific for Bb - Has cross-reactivity with several different types of viruses
34 outer surface protein B (OspB); specific for Bb
35 specific for Bb
37 specific for Bb
38 cross-reactive for Bb
39 is a major protein of Bb flagellin; specific for Bb
41 flagellin protein of all spirochetes; this is usually the first to appear after a spirochete infection but is NOT specific to Lyme (i.e, other spirochete diseases have flagellas - see link above "Western Blot Made Easy" for more info)
45 cross-reactive for all Borellia
50 cross-reactive for all Borrellia
55 cross-reactive for all Borrellia
57 cross-reactive for all Borrellia
58 unknown but may be a heat-shock Bb protein
60 cross reactive for all Borrellia
66 cross-reactive for all Borrelia, common in all bacteria
83 specific antigen for the Lyme bacterium, probably a cytoplasmic membrane
93 unknown, probably the same protein in band 83, just migrates differently in some patients

There are nine known Borrelia burgdorferi genus specie specific KDA Western Blot antibodies (bands): 18 23 30 31 34 37 39 83 and 93.

You have *3 significant bands related to Lyme

Check out this site -http://www.truthaboutlymedisease.com/phpBB3/viewtopic.php?f=10&t=15

Did they test you for co-infections as well?
Posted 9/8/2012 5:02 PM (GMT 0)
Thanks for that. I'm trying to figure out what these numbers mean to me, i.e. is this an active infection, or does it show an past infection. My LLMD has run general coinfection tests but not through Igenex. I have to pay for everything (except Labcorp) out of pocket and I literally have no more money for tests right now.
Posted 9/8/2012 7:36 PM (GMT 0)
I know, the tests are very expensive. My LLMD just ordered tests through Igenex ($1140) and Lab Corp (covered my GoldenRule). Do you have insurance? I'm submitting a claim form for the blood tests and LLMD visit. She thinks that I will definitely get reimbursed for some of the costs.
Posted 9/8/2012 8:52 PM (GMT 0)
The numbers correspond to protein bands. See the link mentioned at the end of my post for more info on this.

Most LLMD's would assume you have active infection based on these test results, because there are IgM antibodies that are specific to Lyme, and it is actually more common for IgM antibodies to be present in chronic Lyme than for there to be IgG antibodies...

This is because the bacteria that causes Lyme constantly changes its outer surface proteins, thus requiring the immune system to always be generating new antibodies (IgM are "new" antibodies, and then after a few weeks, these IgM antibodies get converted into IgG antibodies).

Here's an interesting page:
/sites.google.com/site/drjoneskids/lab-tests/tests-explained--dr-crist
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