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Posted 1/27/2013 10:29 PM (GMT 0)
Are there any antibiotics that work for Lyme that don't raise liver enzymes a whole lot?? or bartonella?
Posted 1/27/2013 11:48 PM (GMT 0)
Here is some info that may help:
http://jac.oxfordjournals.org/content/early/2011/05/17/jac.dkr159.full
Posted 1/28/2013 1:59 AM (GMT 0)
Not sure. I do know that Rifampin can raise liver enzymes a lot, which is for Bart. That's one to be cautious w/ if you're having problems. Also, my LLMD put me on a liver support supplement. It contains milk thistle among many other things. She said that she has never had a patient w/ liver problems that went on the supplement. My ALT was elevated and is fine now after being on it. I would ask your LLMD about that.
Posted 1/28/2013 4:06 AM (GMT 0)
Yea, my concern is that I believe the Bart and the Lyme have had a stronghold in my kidneys and milk thistle is hard on the kidneys so...not sure exactly where that leaves me. I started taking a liver detox/natural normal cell regeneration twice a day that doesn't include milk thistle and my eyes go from being a little yellow to not at all during the day. It is weird, I guess it is okay as long as it doesn't get worse. I believe I'm also allergic to ragweed so...I'm kind of worried about trying milk thistle. I'll check it out though.
Posted 1/28/2013 4:35 AM (GMT 0)
My LLMD has me on sarsaparilla in addition to milk thistle. NAC is also supposed to be good for detox and producing glutathione.
Posted 1/28/2013 5:05 AM (GMT 0)
opugirl,

Heather's liver enzymes were highly elevated while she was on certain antibiotics. Later, her liver enzymes reduced too near normal levels after she was put on Minocycline and Bactrim to hit the Bartonella hard. She was also on some of the Cowden and Buhner protocol products at the same time.

Heather had been on doxycycline, but we requested that she be treated with Minocycline instead, because we were going into summer. Mino creates a lot less photosensitivity. Both are members of the tetracycline family. Mino has a longer half-life, and therefore requires only half as strong of a dosage. Instead of using 200mg dosages, we were able to use 100mg dosages. We also had an electro-dermal test performed for compatibility before she took any of the Mino. The Mino was tested to be a lot less toxic to Heather's system than the doxy.

This cannot be construed as a tightly controlled experiment by any means. However, Heather's liver enzymes went down and stayed down while she was on the Mino for 5 months, while they were elevated while she was on the Doxy. Mino is effective for both Borrelia and Bartonella when used in conjunction with other classes of Abx. It supposedly has good tissue penetration as well. I hope that this helps you! As they say, every patient is unique and different.

Don
Posted 1/28/2013 1:43 PM (GMT 0)
Hi Don,
If you don't mind, I'm curious about Heather's Mino dosage. You said that she was able to take 100 mg doses instead, can you tell me how many doses a day? Was it the standard 3 times? I was wondering because I've always been told that the Mino dose that I was on was quite high (300 mgs 3 times a day for a total of 900 mgs a day) and I've wondered off and on if that contributed to my body 'melt down' from the abx. The doc that I was seeing at the time didn't do any kind of compatibility testing with me.

My Doc at the time told me that Mino had smaller molecules so it could penetrate the blood/brain barrier easier as well, although I never did check on that to see just how true it really is.

Also a word of warning to anyone who is fair-skinned - still be very watchful when out in the sun!!! I burned pretty bad while on Mino. LOL! Even my knuckles would get sunburned when I drove the 5 hours to get to my LLMD at the time!!
Posted 1/28/2013 7:23 PM (GMT 0)
OMG Traveler, you were on 900 mgs per day!!!! Holly Cow, no wonder you were so sick on it!!!! My Dr. has me on 200mg per day and, from what I've read, that's the standard dosage for Lyme.

My LLMD did tell me that mino. penetrates the blood/brain barrier better than most abx.

Don-I didn't realize that Mino. hits Bart also. I'm on Mino. and Rifampin for Lyme and Bart. Was on Ceftin also, but my LLMD took me off of it for now because I really haven't been feeling well. Do you know if Ceftin reaches a different form of the Lyme (like L form) than the Mino.? Off topic, but just wondering.
Posted 1/28/2013 7:34 PM (GMT 0)
about to say the same thing: OMG - that's a huge dosage Traveler!
I was already feeling so sick taking 200mg a day that I had to change the abx combination...
Posted 1/28/2013 7:42 PM (GMT 0)
Sounds like your dose was way too high, Traveler!

"Because minocycline is so highly lipid soluble, 100 mg orally q12h is comparable with 400-mg daily doses of doxycycline in terms of CNS concentrations which are also in excess of the MIC90 for B. burgdorferi."

http://cid.oxfordjournals.org/content/30/1/237.2.full
Posted 1/28/2013 9:22 PM (GMT 0)
Hmmmm. me thinks something went wrong! Maybe that's why after 12 months on that dosage I just couldn't take any more and I felt so doggone toxic!! My body first started malfunctioning, then after I quit taking them I realized that my body had started shutting down.

My doc was diabetic, and was starting to have real problems with it when I was seeing him. Maybe he shouldn't have been practicing at that point? Oh well, at least I survived it!! turn

Opugirl,
Please forgive me for highjacking your thread!! blush It was unintentional!
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