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5-MTHF 5mg

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Posted 4/30/2013 2:35 AM (GMT 0)
I know there has recently been a lot of talk about the MTHFR mutation. Is anyone taking this, and have you noticed any improvement? My LLMD said to take twice daily, and *if* it helps I should notice an increase in energy within a month (yippee!!!)

I'm heterozygous for C (I hope I said that right, only one gene is mutated).

Thanks! :-)
Posted 4/30/2013 3:03 AM (GMT 0)
Yes, I am taking 5000mcg in combo with 5000mcg Methyl-cobalamin.. I think you must take both or you risk methyl trapping
I ramped up starting at 1000mcg, adding 1000mcg per week, it opened my detox pathways, that is for sure, and my brain fog is gone.

I have 1298C and c667t, single of each

Post Edited (PathogenKiller) : 4/30/2013 7:34:45 PM (GMT-6)

Posted 4/30/2013 4:40 AM (GMT 0)
I was told I have a "double" gene defect, so Im taking the Methyl B12 and Folate (L-methylfolate/Metafolin variety) orally. I do not believe I have noticed any change so far.

However, I get monthly B12, glutathione and magnesium shots and I do feel somewhat better after these. I may need to discontinue as they are proving to be expensive and are not covered by my insurance. =(
Posted 4/30/2013 10:15 AM (GMT 0)
I haven't been tested, but I also feel much better from glutathione IV's. I do my own B12 shots daily. It's not expensive from infuserve; about $50 per month shipped for 1mg daily of methylcobalamin. The B12 greatly improves my psychological well-being. It suppresses anxiety and depression but doesn't give me dramatic increases in energy.
Posted 4/30/2013 11:38 AM (GMT 0)
I tested positive for two copies of A1298. I started b12 and l methyl folate and had adverse symptoms so had to stop. I found a practitioner who understands this better than I think my llnd did. We are doing further testing with 23andme. Until I get those results I'm working on my gut health. Apparently they are likely other mutations ill need to address first.
Posted 4/30/2013 10:30 PM (GMT 0)
Yes, other mutations sometimes need to be addressed first.

Also, some doctors recommend too large a dose of L-MTHF or B12 at first. The key is to start with tiny doses, maybe not even every day, because the adverse symptoms can be from detoxing too much at once with the larger doses of the supplements.
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