MTHFR C677T and A1298C mutations and FL1953 :(

So... depending on your perspective, I've had a good day or a really crappy day.

Test results just came back confirming the MTHFR C677T and A1298C mutations and FL1953 (although I'm a little confused about the lab results - more below). I am worried about these results, as I have so many other things going on (various viruses and the lyme & co-infections and Lord knows what else I haven't yet discovered)... Hoping someone else as input? Experiences to share?

I guess for the gene mutations I need to find the right supplements but I'm curious what those are in the context of the lyme & co. I have a query into Dr. Lynch (so many great vids on YouTube about his research on MTHFR) so we'll see what he says. I read a great article by him about the accuracy of DNA testing (such as done by 23andme.com) and it's clear that with what I now know, the most comprehensive approach is going to be a full workup to take in the whole picture.

Protomyxzoa Rheumatic (formerly FL1953) lab notes say:
"Few (501) organisms per total fields observed) coccobacilli (arrow on my slide pointing to it). This is suggestive of epierhthrocytic bacteria or an unspecified infectious and/or parasitic disease. Few biofilm community-like structures were observed. Visible structures suspect of protozoan embedded in biofilm communities (arrow on the slide pointing to it)."

I've been on the internet searching and reading and coming up mostly confused and upset. Interestingly, epierhthrocytic bacteria is a cousin of Bartonella. Studies showed that with low-fat diet (and all the other restrictions I'm on) people test with lower levels of the protomyxzoa, which would suggest that this was much more prevalent before I started the food restrictions (so why don't I feel a lot better now?) But I have read on a couple sites that it's curable... so let's do THAT.

-p

I had the Fry "Special Stains" test done - it is an interesting test, and as your test also indicated, it is NOT SPECIFIC or indicative of any one particular bacteria or parasite ...

Pirouette, my test said the same thing as your test :

This is suggestive of epierhthrocytic bacteria or an unspecified infectious and/or parasitic disease

This could be bartonella ... it could be babesia ... it could be something similar to either one, or, any one a dozens of strains of either of those ...

I had no biofilms detected, and my "unspecified" microbe came back a "rare 1-4 organisms per field" ... of course, this is simply what was in the blood sample taken from my arm that day ...

Personally, I think the entire biofilm hysteria is completely unfounded - Stephen Buhner talks about this and he makes the most sense ... Just about every bacteria can form a biofilm, and everyone has biofilm formation in them ( dental plaque is biofilm from microbes ) ...

These parasites and bacteria have been around for thousands / millions years ( depending on your belief ) and it is quite ridiculous that all of a sudden we have this new super biofilm creating parasite ...... if anything, these parasites are opportunistic and have taken advantage of environments in our bodies that are favorable to their survival ...

The "no fat diet" to limit biofilm is almost as bad as the Marshall Protocol disaster of "no vitamin D" ...

I would think a combination of babesia and bartonella remedies would be good, perhaps with the emphasis on the anti parasitic type - a lot of people find Ivermectin or Biltricide effective

I have always reacted to artemisinin - in fact, I just started it again tonight

Thanks for the responses -

I was reading up on some of Klinghardt's literature - found a good quote:
"The treatment approach that Dr. Klinghardt uses consists of four main steps. These are: 1) Correct basic physiological parameters (pH, electrolytes, HPU/KPU, constipation, hormones), 2) Immune Modulation (which accounts for most of the symptoms), 3) Detox of biotoxins and exogenic toxins, and 4) Decreasing microbial and parasitic burden. Note that the last step is killing the microbes. - See more at: http://www.betterhealthguy.com/physician-s-round-table-2012#sthash.1UpCLYdP.dpuf"

...and I realized that is what my LLMD has been doing. And I get discouraged because the last stage of killing the microbes seems---or is a long way off.

I don't know if I have Bartonella or Babesia but I have as many of the same sx for both as I do for Borrelia. I don't really want to do more testing for them but the more I read it seems like treatment gets specific so I guess I'll be spending more $ to do that. I have also read that some researchers aren't convinced of these IGeneX tests and suspect there is more going on than what is being revealed.

Tano -
What does your sensitivity to artemisiae mean - and does the homozygous MTHFR A1298C cause issues?

-p

Homozygous 1298C is not good and that can have you feeling the way you do. I have a similar infection although I don't believe I have a problem with Borrelia. I hate to say it but your treatment will be difficult, but you can get better.

A 1298C is a 40% reduction in enzyme function so with the 677T, you've only got just under 50% of that pathway working. I'm in the same boat. This pathway helps with detox so I would surmise that you have metal buildup (like I have.)

I would not go no fat as you need it for proper cellular functioning, but I would eat much smarter. There is much more than I can put here, so if you wish to email me, feel free.

Pirouette, the image is not great but if you had a lot of Protomyxzoa your red blood cells would be hollowed out. You only have several. I cannot see the biofilm so I can't say anything about that. The biofilm is where mold and heavy metals hide too. Let me know when the hard copy comes in. The cells look rounded so I don't think it looks like you have a mold problem.

With methylation defects, the body sequesters the metals so they don't show up on the hair or urine tests.

Need to deal with MTHFR before KPU. KPU requires massive doses of minerals and MTHFR makes it tough to tolerate until the glutathione level is back to normal (MTHFR mutations can lower glutathione).

There may still be mold in your nerves and brain but you have done a great job cleaning out of your blood so that's good! That is a very good sign.

@PIROUETTE re A1298C GENETIC MUTATION

I also have the A1298C Gene.

BACKGROUND, My mother, 8 of her sisters, my grandmother, many first cousins related to her - currently have senile dementia or have died of senile dementia. Now my older brother has it and is dying of this terrible condition.

about 3 years ago, when I first noticed my brother had it too, I had a meltdown in my doctor's office. Without telling me, he did some testing and found this gene mutation.

THE BAD NEWS is that this can cause some bad stuff to happen in your body. It prevents your body from utilizing folic acid. Without folic acid the blood circulation to the brain is compromised and the brain slowly dies. It looks just like Alzheimer's if you live long enough. It is inherited.

THE GOOD NEWS is that you can turn it around (but it does take years to calm the inflammation in the brain down....and it is too late for my brother). I have been on it for 3 years and may have dodged a bullet.

FOLIC ACID - 2400 mcg dose - every day for the rest of my life. Also Niacin (non flushing kind) 500 mg every day for the rest of my life.

NIACIN - 500 mg of the non-flushing type daily to strengthen blood vessels and keep them healthy. But Folic Acid is the most essential one here.

So far so good. After 3 years of taking this I have reached the age where my mother and brother began to show signs. So far - I have none.

My children are much younger, but they assume that they have this too and are taking Folic Acid and Niacin to protect their brain function until they cna be tested.

You cannot overdose on Folic Acid and Niacin (non flushing type is preferable) so there is no problem. However, the consequences of not taking these high does daily to override that gene is pretty horrific.

I hope you see this post...and I hope it helps you.

Post Edited (Painter Wells) : 6/2/2014 6:20:06 PM (GMT-6)