Hi Levin,
Welcome to our community! I'm so sorry to hear about
your Uncle. Do you suspect that he wasn't treated properly or that he got no treatments? Something to keep in mind, most often the insect that passes Lyme to us will be carrying other bacteria (such as Bartonella, Babesia, as well as other bacteria, viruses and molds) that can make his symptoms worse. Many well respected Lyme literate medical researchers/doctors now say that when Lyme is combined with Bartonella, many of the Central Nervous System symptoms will be more severe.
Here are a few articles that I found, I hope that they are what you are looking for. If not, maybe you could define what you are looking for a bit more?
www.psychologytoday.com/blog/why-can-t-i-get-better/201402/antibiotics-found-effective-in-schizophrenia "A controlled clinical trial was just published in the psychiatric literature, showing that minocycline is effective in treating negative symptoms in early phase schizophrenia."
"yme disease causes a wide range of psychiatric manifestations. Published research has shown a higher prevalence of antibodies to Borrelia burgdorferi in psychiatric patients than in healthy subjects. There is also a known geographic correlation of schizophrenia with ticks and tick-borne encephalitis, with peer reviewed literature showing an association of Lyme disease with schizophrenia. Other tick-borne infections, such as Bartonella (cat scratch disease) have also been reported to cause neurological and neurocognitive dysfunction, as well as causing agitation, panic disorder and treatment resistant depression. Minocycline, as well as other tetracycline antibiotics like doxycycline, are well known treatments for neurological manifestations of Lyme disease and associated co-infections like Bartonella. It is therefore plausible that a certain number of cases of severe psychiatric presentations are due to underlying infections, especially since Lyme disease is the number one spreading vector borne infection in the world."
www.ncbi.nlm.nih.gov/pubmed/21648354" In the chronic stage, many months or years after the initial infection, other neurologic complications may occur, such as encephalomyelitis, epileptic crises, cognitive impairment, peripheral neuropathy and psychiatric disturbances such as depression, anxiety, panicc attacks, catatonia, psychosis etc. Some patient continue to experience symptoms of fatigue, insomnia or psychiatric disorder in the post borrelia syndrome. We describe here a patient with a triad of unusual symptoms in chronic LNB including tremor, seizures and psychosis."
/www.holtorfmed.com/download/chronic-fatigue-syndrome-and-fibromyalgia/Lyme_Disease_and_Psychiatric_Disorders.pdf"In a published study one-third of psychiatric inpatients showed signs of an infection with the Lyme spirochete, Borrelia burgdorferi. It has been found that that even severe neuro-psychiatric behavioral symptoms in this population can often be reversed or ameliorated when a multi-system treatment program targeting Lyme disease is used. Patients with late-stage Lyme disease may present with a variety of neurological and psychiatric problems, ranging from mild to severe."