Not sure if it absorbs other stuff besides ammonia. I always took it with food and my other supplements without noticing any problems...but then I have a rather strange stomach...
See Dr. Yasko's ammonia protocol for more info about
how to know if you're getting enough yucca root:
www.dramyyasko.com/resources/autism-pathways-to-recovery/chapter-6 - search the page for "yucca"