I'll answer
I actually felt worse (!!!) when I began treating. Out of the gate I started the methyl-folate and had over-methylation symptoms right away (within an hour) of major muscle cramping.
Did a little digging and researching as well as ordered the 23andme test and found that I had the COMT and VDR which caused me to not tolerate methyl donors (the methyl part of the folate) and that I needed to take hydroxy b-12 to mop up the excess methyl groups in my body before I would be able to tolerate the methyl-folate.
Once I got that going, I would sometimes get muscle pain in the beginning but that has passed and since then I have noticed having a little more energy and motivation but nothing major.
I feel better taking it though knowing that long term it is contributing to a healthier body (less cancer risk etc). I will say that with the double mthfr mutation that I have (for c677t) I have felt a freedom knowing that my previous pregnancy losses were nothing to do with anything I did health or nutrition wise and everything to do with the mutation itself.
I plan to take the methyl-folate and hydroxy b-12 for the rest of my life just for prevention sake. I should note I have a double MTRR mutation that causes my body to rapidly cycle b-12 so I have an increased need for it too. The 23andme test is $99 and helped me to know how to treat.
Best!
PS - Wanted to add that I take less than 400mcg methyl-folate a day though - a very, very low dose along with 2000mcg (2mg) of b-12. So I know I have taken it really easy and slow as far as triggering any detoxing reaction that high dose methyl-folate might have on lyme patients. I will slowly keep raising the dose over time to what is comfortable for my body.
Post Edited (SLML) : 3/2/2015 5:28:24 PM (GMT-7)