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does anyone know anything about the HLAB27 gene?

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Posted 3/25/2015 4:03 AM (GMT 0)
A friend of mine has been struggling with loads of pain over the past few years.

she was diagnosed with Ankylosing spondylitis / psoriatic arthritis because she tested positive for this gene. She has severe back pain, iritis, and joint pain. She is only 40 - and it all came on suddenly a few months after she gave birth to her third child......

weird right? first thing I thought, could it be lyme? i asked her if she gets any tingling sensations or numbness, and she said sometimes down her leg and her tongue......she lives in Chicago now but lived in NY most of her life.

I don't want to be going around diagnosing everyone with lyme - but she is the first person that is waving a red flag since I became familiar with all this. I just don't know how accurate that genetic test is....

any thoughts?? thanks!!
Posted 3/25/2015 4:45 AM (GMT 0)
I read about it when I was searching the 'net' to figure out what could be wrong with me... pre lyme.
The back/joint pain is inflammatory in nature (as opposed to mechanical) - so it is possible that Lyme disease could cause it (we all know about Lyme=inflammation)

Although 90% of people with ankylosing spondylitis have the genotype, only about 2% of people who have the gene have ankylosing spondylitis.

So I wouldn't be convinced of the diagnosis if all they're going on is back and joint pain coupled with the HLBA27 gene.

Did inflammation show up on an MRI?

Since Lyme I have a lot of doubts about certain diagnoses where there is not a clear-cut diagnosis and treatment.
What is causing the inflammation in the first place? Could it be Lyme?

I'm not saying it's Lyme - and it's difficult to even talk to someone about the possibility when they haven't experienced what we have with Lyme disease and the misdiagnoses.
Many people are relieved just to have their diagnosis and don't want to even question it.
For me - I didn't want a diagnosis that couldn't be treated.
Posted 3/25/2015 8:55 AM (GMT 0)
If I were in her condition, I would eat a completely alkaline diet and go from there. You wouldn't believe all of the bacteria that grow in synovial fluid at just 0.1 lower pH than an optimal pH.

We have an estimated 100 trillion bacteria in our GI tract. Eating a typical American diet, you would also be amazed at how many of those bacteria and yeasts are antagonistic to good health.

Post Edited (Georgia Hunter) : 3/25/2015 4:19:02 AM (GMT-6)

Posted 3/25/2015 10:36 AM (GMT 0)
Girlie - thank you - do you have a link where it says that only 2% of people actually have it? that's the type of stuff I am looking for.

I don't want to come out of the blue and spring the possibility of lyme on her, especially if I may be wrong. But this whole thing seems so fishy to me.

Georgia - I totally agree with yo on the bacteria and yeast issue, but if she indeed does have an autoimmune problem due to a genetic disposition, would diet indeed help?

thanks!
Posted 3/25/2015 11:30 AM (GMT 0)

Chapelle said...
Girlie - thank you - do you have a link where it says that only 2% of people actually have it? that's the type of stuff I am looking for.

I don't want to come out of the blue and spring the possibility of lyme on her, especially if I may be wrong. But this whole thing seems so fishy to me.

Georgia - I totally agree with yo on the bacteria and yeast issue, but if she indeed does have an autoimmune problem due to a genetic disposition, would diet indeed help?

thanks!


It would help tremendously. In auto immune disorders, our body doesn't attack itself, it attacks a pathogen that is attached to us. The inflammatory process is what messes us up. Diet also reduces pathogen growth which can decrease inflammation. We all have genetic issues, some of us just have worse issues than others. I didn't think diet would cure my arthritis but it did. Some people just don't have the willpower to eat strict enough.
Posted 3/25/2015 12:04 PM (GMT 0)
"In auto immune disorders, our body doesn't attack itself, it attacks a pathogen that is attached to us"

Georgia - this makes perfect sense! But I never knew this - I honestly never understood how our own body could attack itself - but this explains it! do you have a link to this fact by any chance? just trying to get my info together so I don't just come out with all of these ideas for my friend without backing up my data!! thanks.
Posted 3/25/2015 12:26 PM (GMT 0)
I studied this a couple of years ago when I had arthritis and I didn't save links back then. Our immune system looks for abnormal proteins and things like LPS. When these pathogens attach, they often still have exposed proteins that our immune system can recognize. When our science gets more advanced, they will find that atherosclerosis is due to an immune response of the body trying to protect itself against an invasive pathogen. They have already found the bacteria on the plaque, now they just have to determine the mechanism.
Posted 3/25/2015 1:47 PM (GMT 0)
thanks again Georgia - I don't have time to look for links, so she will just have to trust my references - you guys! =)
Posted 3/25/2015 5:46 PM (GMT 0)
I, too always wondered about the body attacking itself...isn't it smarter than that...that makes sense Georgia - body recognizes the pathogen and attacks it...the collateral damage is what's affecting us.

Chapelle - here's a link:


I took the link out -it isn't working for some reason.


"What is the HLA-B27 gene?
HLA-B27 is a perfectly normal gene found in 8% of the general population. Generally speaking, no more than 2% of people born with this gene will eventually get spondylitis. The gene itself does not cause spondylitis, but people with HLA-B27 are more susceptible to getting spondylitis."

Also - it greatly increases if other family members have it.
I'll try the link again:

www.spondylitis.org/about/as.aspx

You might have to just go to type the website in.....- it's coming up with an error...
Posted 3/25/2015 6:09 PM (GMT 0)
BTW - when I was reading through the information recently (you got my interest piqued...) I also read on one website that they're thinking that a bacterial infection could 'trigger' it.

Now, that makes sense, doesn't it? The bacterial infection causes the inflammation, which in turn causes the damage to the spine.

I know whatever diagnosis I was going to be given...i wasn't just going to accept that I would be in pain, crippled...etc. I was/am not going down without a fight.
I believe there is a cause and we are just not searching for it.

Maybe antibiotics should be tried for most of these non-treatable diseases that plague so many people...I mean really...something is causing it...
or may be something as simple as a food sensitivity - as in Celiac disease. yes, there's a gene responsible...but you stop eating gluten, your body recovers.

We're giving up too easy....fibromyalgia? What's with that...just take pain killers the rest of your life? (and sleep aids, and anti-depressants)
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