Raised PGE2 and IL8 what does it mean?

MY llmd did some blood including cd57 and VEGF and other IL s interleukines
Only the pge2 il 8 was raised pge2 13,5(nl max 5,5) IL 8 increased 1000x over normal value and MCP1 incresed and cd57 low as in 50
What does it mean.
I think it hasto do with the malfunction of the immune system, I dont know if it means your immune system is supreesed or is it overacting?
MY LLMD only said it fits with the diagnosis of lym
PLease can anyone shed a light on this
thx jack

Hi Jack,

High PGE2, IL-8 and MCP1 (the 2 latter are cytokines) means, in short, that you are herxing and that inflammation is up.

Prostaglandine 2 (PGE2) is a hormone like substance that has a inflammation moderating function (amongst other functions). The substance is released as a reaction on infection or inflammation.
My highest level ever was 39, if I remember well. I know someone who' levels were in the 60's. It went remarkably down when I had to pause my treatment.
In short, cytokines regulate the immune system responses and can drive the inflammatory process. High cytokines can bring on flu-like symptoms including fever, achiness, and fatigue.
Sleep deprivation can bring up one's cytokine levels.
As for my personal experiences: I used to not listen to my body when it shouted out that I needed to rest. Then I had an accident and started to sleep a lot, stopped working, and had to temporary stop my treatment. My IL-8 level went from 60450 to 540. I couldn't believe it.

It is normal to have high PGE2 and elevated cytokines when under treatment for Lyme. Your doc will probably prescribe you Omega3, NSAID's, and maybe up your detoxing with Glutathione.

Oh, my cytokines were already out of range before starting treatment (I don't know about PGE2 because that test wasn't done back then).

These hugely out of range test results are really scary, but are sadly part of the process. You will have to take supplements and drugs to try to bring inflammation down.

I hope this helps Jack,

Marie