I live in Arkansas, some some consider it part of the Midwest, so I thought I would answer.
I used what is known as the Chronic Tonic. I was seeing a Master herbalist and she told me how to make it as a medicinal tea (decoction) as seen here:
www.healingwell.com/community/default.aspx?f=30&m=3244272.
I have healed twice now - once from a 40 yr infection the first time (2010) and a 3 month old infection the second time(2014) using just it for my Lyme infections.
I didn't have any trial and error, although the CT did kick my rear for 3 weeks when I started it.
From what I've seen, there is less trial and error for those that choose to go with only herbs - although there may be other herbs that are necessary (other than the ones in the protocol) to help deal with symptoms or die off issues.