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Who else feels "stuck" from detox issues from genetic mutations?

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Posted 9/6/2015 3:45 PM (GMT 0)
There has to be a lot more with this that are unaware, think of all the people dxed with fibro. This will be huge some day. Methelation issues have to play a part in many chronic illnesses, I would think. It might even make the difference in getting chronically ill to begin with in some cases. If your body cant get the bad stuff out, or convert minerals into chemicals like it should, your body doesn't work right. Its like pumping diesel into a gas car, it will barely run.

Methalation is new, very complicated health science. There are very few forums on it, daily activity on them is rare. Hopfully this improves.

***So who else here feels stuck from this?***

I've spent a lot of time and money with two Drs that know some of this, still I get nowhere. One Drs eyes just lit up when he saw all my red double copy mutations. You cant treat all genetics deficiencies at once, but if you have a lot, its seems helpless. Surprisingl,y the common MTHFR, is one I dont have double copies on. Plenty of others though, many liver related.

Not trying to be a downer, but I do feel stuck, its complicated, more than just lyme. ABX is very hard on me, to say toxic-ally dangerous to my body is not exaggerating, which is why I stopped it. So I dont know if lyme and company is gone or not with so many overlapping symptoms of that, thyroid, candida fungus and genetic mutations.

This is way to much to discuss with siblings, its WAY over their heads and tolerance level of hearing about their sick brother.
Posted 9/6/2015 9:34 PM (GMT 0)
bump
Posted 9/7/2015 12:03 AM (GMT 0)
astroman, I'm right there with you. I must have some severe methylation issues (homozygous mthfr 677t plus nasty pathogen mix and load) because I have a very very very hard time tolerating meds that kill pathogen. And I know it is a herx and not allergies as I get the same specific symptom flare-ups from different effective meds.

A few months back I had been trying to power thru a new drug treatment but was beginning to get to the end of my rope from the herxing, feeling like I was just going insane from the die-off or whatever. I ended up taking a drug the dr had mentioned, montelukast, I really wanted to avoid it but it helped reduce the herx from making me feel like I was going insane to just moderately terrible. That doesn't sound like it was very helpful but it was a life saver and helped me tolerate and continue the meds and eventually reach a new level.

The only problem with montelukast is that it can be immunosuppressive, but my view is that if it can help me tolerate treatments and the severe constant herxheimers I always get then the benefits outweigh the negatives.

So not saying it is right for you, but just saying might want to ask drs about those angles if you do end up having to get back on abx or killing meds. I don't know enough about the specific supplementation angles for the different mutations, but I hope you can find something to help you soon. Keep hanging in there.

I'm sure other members will be able to give you some ideas.
Posted 9/7/2015 1:38 PM (GMT 0)
Hey there,

I posted about this the other day... What has given my body the boost I feel it needed to help the treatment I'm on be more effective....

A liver cleanse

Like I said in my post about this, if you don't change the oil in your car, it'll run sluggish. A liver cleanse is like an oil change...... We can eat the most organic food, be on the best natural protocol, yet STILL need to "keep our oil changed".... I mean, makes sense, right? Look at all the toxins being filtered through our liver every minute of ever day...

Here are some symptoms of an over stressed liver:

-Digestive Problems
According to Paul Pitchford, author of the book “Healing with Whole Foods,” a sluggish or congested liver may lead to digestive discomfort. Constipation, distended abdomen and ongoing indigestion all relate to liver stress. The stomach may feel bloated and uncomfortable, especially after a meal. The liver is supposed to release bile that helps to break down food and lubricate the intestines. In weak or stressed livers, this process may be compromised leading to these digestive problems.

-Aches and Pains
The liver helps to purify and produce new blood. When it isn’t working in a balanced manner, sufficient amounts of healthy blood may not be reaching tendons, muscles and tissues. This may result in a lack of flexibility of muscles, tendon and muscle problems, tension in the upper back and dry eyes. This constant discomfort can lead to tiredness.-

-Fatigue

If energy through the liver has become stressed or stagnant, this can correlate to the rest of the body. Just as constipation can develop from a slow liver, the body may feel stagnant when the liver is compromised. The liver is also responsible for storing excess glucose for energy usage later but may not be functioning as well as it could. Additionally, if the liver is not removing wastes efficiently, those toxins could also bog down other organs.

-Mental and Emotional Signs and Symptoms
The emotions can become stagnant just like the bodily functions. Feelings of depression or anger are common with liver stress. Stagnation of the liver can lead to resentment, negativity, irritability, tension and mood swings. People with liver stress may have a difficult time making decisions and could feel that they have poor judgment and brain fog. Liver stress can even appear as mental rigidness, aggression and explosive outbursts of emotion or violence.

-Other Signs and Symptoms
Liver stress can affect all parts of the body. Some people may have ringing in the ears, blurry vision, dizziness and conditions of the toe or fingernails. Menstrual and menopausal problems can also arise.

Read more : http://www.ehow.com/list_6132968_signs-symptoms-liver-stress.html

I know this doesn't address the gene mutations you're asking about, (I'm not sure about all that).....
but, maybe, just maybe, this could help others like it helped me---- to feel unstuck. To give the body the boost it needs to keep on keepin' on....

My cleanse was $20, 15 days. Thislyn detox kit by Natures Way.. No, not a sales person, just a happy customer.
Posted 9/7/2015 2:20 PM (GMT 0)
candleinthewind-

Great info.

Unfortunately (bummer) my body doesn't tolerate milk thistle per using it in the past and muscle testing the herb from a practitioner. I am starting D-limonine again for phase I and II liver detox.
Posted 9/7/2015 7:56 PM (GMT 0)
This is good info. Thank you. I always thought my husband could have methylation issues, but I wasn't sure. How does one test for it? I probably read it somewhere but forgot. Heavy metals is more than likely even more of an issue for him being that he worked in electronics. I think I will order a Milk Thistle product for him.
Posted 9/7/2015 8:47 PM (GMT 0)
I also have the methylation issue and have found that my body rejects anything I take to destroy a pathogen.

The absolute worse is synthetics. Natural herbal treatments, as long as they're not from China because of the toxic heavy metal laden soil there, herbals are the closest to nature-well that's because theyre 'natural'.

Pharmaceuticals are herbals on speed= they've been chemically altered sort of like what they've done to our food=GMO! Eeeeek!!!

With that said; some of those chemicals are helpful only for severe pain & emergencies such as surgery...
Posted 9/7/2015 10:30 PM (GMT 0)

Cat53 said...
This is good info. Thank you. I always thought my husband could have methylation issues, but I wasn't sure. How does one test for it? I probably read it somewhere but forgot. Heavy metals is more than likely even more of an issue for him being that he worked in electronics. I think I will order a Milk Thistle product for him.

Most people here just order the 23&me testing kit: /www.23andme.com/
Posted 9/8/2015 12:02 AM (GMT 0)
I certainly feel stuck - my methylation variants are big contributors (in my opinion) to my digestive and immune system problems, and the inability to tolerate the die-off from the Lyme treatments.

Before this latest round of total digestive shut-down, I was taking the supplements for my double-mutation CBS variant, and it still wasn't enough to prevent the gut shutting down (probably thanks to contributing issues of Lyme/coinfections and allergies).

But now I can't even take any of the supplements for the mutations, because of the gut shut-down (gastroparesis is linked to low BH4, which detoxes ammonia (a known Lyme neurotoxin)...and my methylation variants cause low BH4).

So yeah, I certainly feel stuck. I don't know what to do next, and neither does my doctor...

Ok, so for those wondering about methylation, here's some info:

Best info is at dramyyasko.com -- read the free book "Pathways to Recovery" (it says Autism in the title, but it pertains to most all chronic illnesses).

Condensed info (much more technical) is here:
www.heartfixer.com/AMRI-Nutrigenomics.htm

For testing:
Dr. Yasko Methylation Panel (looks at 30 SNP's all related to methylation):
www.holisticheal.com/health-tests/nutrigenomic-testing

23andme.com looks at a lot of genes, for genealogical as well as others, and some but not all of the methylation genes are included.

For 23andme.com results analysis, there are many sites. Some are mentioned at the second methylation link above (heartfixer). You can get the methylation genes from your 23andme.com results analyzed for free on Dr. Yasko's site here:

knowyourgenetics.com - join for free, then plug in your methylation gene results from 23andme.com and you'll get a free report on what supplements to use to help compensate for each variant SNP. Use the protocol given in the first methylation link above (Dr. Yasko's book) to implement these supplements...and it is best to work with a health care practitioner on this because it is so complex.

I hope this info helps...
Posted 9/8/2015 3:47 PM (GMT 0)
Razzle-

I think the issue we have (those with many mutations) is the order at which we treat these mutations. Its just to big of a puzzle.

Thats why I'm thinking of LDN, since I have Hashi autoimmune, putting the brakes on this might help from things getting more out of control. I'm a little skidish on trying it, since so many treatments backfire on me. (sitting here as my body slightly tingles).
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