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Posted 10/28/2015 5:30 PM (GMT 0)
Manganese can decrease BH4 so it must be supplemented carefully in low doses.

Manganese deficiency shows up as low cholesterol and increased alkaline phosphatase.

Manganese helps detoxify ammonia. If you are low on manganese, you will not detoxify ammonia very well.

Manganese helps to make dopamine. If you are low on manganese, your neurotransmitter pathway will not work with great efficiency and that can lead to depression, insomnia, anxiety, panic attacks, etc.

Manganese is required for insulin production. If you are low on manganese, your blood sugar may run high.

Molybdenum is often required for detoxifying.

Molybdenum maintains the zinc/copper ratio. Elevations in copper can be due to a lack of molybdenum.

Magnesium Sulfate should be avoided in CBS upregulation.
Posted 10/28/2015 6:58 PM (GMT 0)
Thanks Georgia Hunter. Very interesting.

What is considered a low dose for manganese?
Posted 10/28/2015 11:19 PM (GMT 0)
It's in our water, so I don't know if we absorb it much or not. Our filter takes a lot of it out. Our doc said our levels are fine.
Posted 10/29/2015 12:00 AM (GMT 0)
I've seen Manganese doses of 250mcg, 1.5mg, and 40mg. The first two would be low doses IMO.

We all eat manganese in the foods we eat and some get it in their water. The problem that can occur is through constant inflammation, manganese is depleted intracellularly. Manganese is a substrate for several important reactions including binding to polyamines for intracellular transport. Manganese exists mostly inside the cells and testing for accurate levels is problematic.

The cytokine cascade takes a toll on us over time and intracelluar polyamines decrease. This causes us to age, to function less efficiently, and to produce free radicals. So in a sense, having Lyme accelerates our aging process.
Posted 10/29/2015 2:16 AM (GMT 0)
Thanks GH. That makes a lot of sense.

I need to work on decreasing my cytokines and inflammation.
Posted 10/29/2015 3:18 AM (GMT 0)
This is very helpful information, thank you!

Manganese deficiency can also cause tight muscles and deformities.
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