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Does anyone know what ELQ-334 is? 'New' Babesia treatment possibly

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Posted 6/9/2016 9:30 PM (GMT 0)
news.yale.edu/2016/06/06/combination-therapy-cures-tick-borne-illness-mice

Now it's only been tested to 122 days of no recurrence, but at least it's a start.

"For their study, the Yale-led team first tested in mice with diminished immune systems four drugs that are currently used in the form of two combinations to treat human babesiosis. Only one of those drugs, atovaquone, was effective in attacking a target enzyme that, when mutated, allows the parasite to develop resistance. Using the mouse model, the team observed efficacy with a fifth drug (ELQ) that involves a similar mechanism of action as atovaquone but at a different enzyme target site. They decided to test the two drugs in combination.

The researchers found that the combination of atovaquone and ELQ-334, at low doses, cleared the infection and prevented recurrence up to 122 days after treatment."

But I'm really curious what ELQ -334 is!!!!
Posted 6/9/2016 9:41 PM (GMT 0)
That is the name of the new drug. Just like penicillin, morphine, etc.

I think they could have been more inventive naming it, but maybe it is the initials of the 3 Yale members that concocted it and it was their 334th try.
Posted 6/9/2016 9:42 PM (GMT 0)
I've been googling - to find out what it is - can't find anything to say what class of drug it is...
Posted 6/9/2016 9:44 PM (GMT 0)
endochin-like quinolone (ELQ)

jem.rupress.org/content/early/2016/06/06/jem.20151519.abstract
Posted 6/9/2016 10:51 PM (GMT 0)
Good job Girlie!!
Posted 6/9/2016 11:03 PM (GMT 0)
Awesome job! Thank you, Girlie!! turn I don't use abx, but I do like to try to understand what's used for what so I can be of some help.
Posted 6/9/2016 11:21 PM (GMT 0)
That would be one abx I might be willing to try!
Posted 6/9/2016 11:26 PM (GMT 0)
I just wanna know where can I get me some???? tongue
Posted 6/10/2016 12:26 AM (GMT 0)
I'll be a guinea pig for humans!
Posted 6/10/2016 1:18 AM (GMT 0)
It may be the drug that was in stage 3 clinical trials a couple years ago. From what I've read, it's chemical make up was very promising.
Posted 6/10/2016 2:39 AM (GMT 0)
Ha ha ha! Mustard Seed! :)

Sign me up also! At this point I will try anything to get rid of all this crap.
Posted 6/11/2016 9:46 PM (GMT 0)
"... The parasite can develop resistance to existing therapies, leading to relapses after treatment...."

So on some levels chronic is accepted, but...

Babesiosis, "Malaria-like" is "rare" in humans per wiki & NIH & yet hmmm, these studies do continue...

And the CDC DOES endorse drugs to take to make sure you don't get malaria when traveling:
www.cdc.gov/malaria/resources/pdf/fsp/drugs/atovaquoneproguanil.pdf

Here NIH states that it is rare in humans:
www.niaid.nih.gov/topics/babesiosis/Pages/default.aspx

But this continued research is supported by the National Institutes of Health and the U.S. Department of Veterans Affairs Biomedical Laboratory Research and Development.

Is it me who is confused, or are there some mixed messages??

The Assoc professor who is noted in this study on his site states:

"There are two main topics investigated in this program: vaccine development and drug discovery..."

Hmmmm...

Should anyone want to send any relevant info, this prof does have his contact info listed:

/medicine.yale.edu/bbs/people/choukri_benmamoun-2.profile

CONTACT INFO 
Choukri Ben Mamoun, PhD
Office203.737.1972
[email protected]
Mailing Address
Internal Medicine
PO Box 208056
333 Cedar Street
New Haven, CT 06520-8056
Posted 6/11/2016 10:24 PM (GMT 0)
I get plenty of mixed messages! But I happen to know which message to follow - Ha ha! scool Just like they say that Lyme is a nuisance disease, yet caution us of Lyme carditis and some others, as they are particularly dangerous.

But back to Babesia, they say our blood supply is safe, yet there is this - a pdf put out by the CDC saying that Babesia is in the blood supply: /www.cdc.gov/parasites/babesiosis/resources/babesiosis_policy_brief.pdf
Posted 6/11/2016 11:25 PM (GMT 0)
No wry about blood supply & yet:

"Some manufacturers are working with investigators at blood establishments to develop FDA-approved tests for Babesia for donor- screening purposes."

Seriously---you get bits & pieces from some who try to raise consciousness (i.e. Erin Brochovich ones, like u, Elena). But what ever happened to the Woodward & Bernsteins, the Serpicos???

Ok, rant over (for now!).
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