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MTHFR, methylation cream and feeling worse

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Posted 12/3/2016 10:08 PM (GMT 0)
I was diagnosed as heterozygous for both MTHFR alleles last week (guess that's how you say it.)

My doctor is very concerned with the detoxing of my brain because of certain symptoms. So she gave me the methyl cream to help supposedly detox things and open up the brain some, but I have felt so much worse with it thus far. I'm an emotional wreck and my body feels so sick. Is this a movement of toxins making me feel bad?

Guess I'm just very toxic. I've been getting glutathione pushes once a week for 3 weeks, so I'm guessing that the toxin load has already been moving around.

Thanks!
Posted 12/3/2016 10:29 PM (GMT 0)
This isn't an area I'm familiar enough with to comment MA10, but I know a large percentage of our members share your hurdle.

Are you on something that you can reduce somewhat, to slow down the toxic buildup?

I imagine there will be a good supply of helpful ideas coming your way soon. Keep your head up!
Posted 12/3/2016 10:33 PM (GMT 0)
Here's a link I found on another thread

suzycohen.com/articles/methylation-problems/
Posted 12/3/2016 10:49 PM (GMT 0)
When a detox pathway is corrected, you WILL feel worse, as more toxins will be able to move through and eventually out of your body. I've been through this a few times - and a couple of those times were totally avoidable if I had been on the ball about ordering more supplements!!

Please do more detoxing. You need to help your body move those toxins on out now that they are now "available" to move.
Posted 12/4/2016 1:20 AM (GMT 0)
Thanks so much. Traveler, I can definitely tell there's a build up of toxins. My brain can tell. Isn't it funny how you feel worse so your detoxing takes more effort to do? I'll have to do more of the easy ones like binders and herbs.
Posted 12/5/2016 3:16 PM (GMT 0)
I would add a good Multi-b vitamin and magnesium and see what happens.

What is the name of the cream? I saw a methylation specialist and he recommended his Neurobiologix Neuro-immune stabilizer cream and it totally made me so sick - I developed chronic fatigue and high anxiety plus increase my neuropathy, all of which it was supposed to reverse. Plus he said it could take the place of my b-12 shots and it didn't work. My deficiency came back.

As far as methylation, many doctors don't know enough about it. It's very tricky and sometimes trial and error when treating methylation polymorphisms. When you increase methylfolate, you use up magnesium, b-12, etc which makes glutathione (which then can deplete potassium)...See where I'm going...

Do you have any other mutations, such as MTRR or COMT? Sometimes when you correct one, you cause a backlog in the methylation cycle in an other area.

Lastly, when jump starting methylation, since we are so toxic, it's not uncommon to feel worse. Up your detox for sure!

It took me a year to figure out my methylation. I am now on a compounded methyl b-12, hydroxy -b-12, folinic acid (I have MTRR) and b-6 shot. I take 2 mm every 2 days. Working great.
Posted 12/5/2016 4:00 PM (GMT 0)
cr3ativegirl, good info! We haven't checked for any of the other mutations. I don't think I knew there were any others. Shee put me on the Neurobiologix I believe. It sounds familiar. I was taking it 2x a day and initiated a huge "flare" or whatever you want to call it. Definitely moved too quickly with that one. She later said just do a small dose 2x a week. After I was already dying. haha.

I feel like mine has b12 and b6, etc in it. I didn't know the connection with the magnesium. I already have a magnesium deficiency, so I guess it would be more important to increase the magnesium intake. But where this gets interesting is that I am also taking glutathione IV pushes. She explains it that because of the MTHFR, the glutathione we're injecting doesn't stick around for long.

This is a whole new world for me. I'm pretty clueless when it comes to methylation. Minus I knew I didn't feel well before, and I definitely do not feel well now. lol
Posted 12/5/2016 10:33 PM (GMT 0)
It's tricky. Hopefully you will figure it out. From your list, you've got a heavy load to clear.....I would recommend using a binder (away from meds) so your toxins don't get recycled. I have had a lot of success with Modified Citrus Pectin and Charcoal taken 2 hours away from meds and food. Helpful with flares! smhair
Posted 12/5/2016 10:35 PM (GMT 0)
Also, Aceytl L-Carnitine helps clear the brain toxins.

http://glutathionepro.com/enhancing-brain-health-acetyl-l-carnitine-alpha-lipoic-acid/
Posted 12/5/2016 11:19 PM (GMT 0)
cr3ativegirl, I am taking cholestyramine. Not like I should be, but I do try to get it in a few times per week. I'm having a hard time figuring out where the binders need to go around the other medicine and food. It's nearly impossible. I'll have to look into the aceytl l-carnitine. My brain feels like someone is squeezing it. Gracious me.
Posted 12/5/2016 11:22 PM (GMT 0)
Here is a hyperlink for those that like them for Cr3ativegirl's link: glutathionepro.com/enhancing-brain-health-acetyl-l-carnitine-alpha-lipoic-acid/

I use ALA for the reasons stated in that article, as well as other things. I've been considering trying out Aceytl L-Carnitine, and will likely be trying it after the first of the year. My life is just too crazy right now to try adding in anything new.
Posted 12/6/2016 2:43 AM (GMT 0)
Cholestyramine is tough to work into the schedule. I could only do it 1x a day and my doctor wanted me to do it 4x a day!

I was just ordering more Modified Citrus Pectin and I noticed that several supplements combine it with other vitamins and minerals, so now I am wondering if you can take it with your other stuff, unlike Charcoal...for example this ImmunePCtn has Amount Per Serving

InnunoPCTN Proprietary Blend ... 3.6g
(Modified Citrus Pectin, Green Tea Extract (Camellia sinensis)(leaves) [standardized to contain 98% polyphenols and 45% EGCG], Reishi mushroom (Ganoderma lucidum), Curcumin C3 Complex [Standardized to contain 95% curcuminolds], Grape Seed Extract (95%), Pomegranate Extract(Punica granatum) (Seed +Rind) [Standardized to contain 40% ellagic acid), Boswellia Serrata extract [Standardized to contain 60% Boswellic Acid), Sunflower Lecithin)

Seems like this would be a good think for us Lymies
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