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Georgia Hunter- "Medications changed by the liver (Cytochrome P450 2C9 [CYP2C9] substrates)&quo

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Posted 12/10/2016 10:44 PM (GMT 0)
www.rxlist.com/limonene-page3/supplements.htm

Whats your take on D-Limonene and certain Rx meds that are "changed by the liver" in pain English?

Will certain said meds (there are more to this list than mentioned on the link) be increased or decreased in effectiveness? I see the D-limonene's effectiveness might be altered (no big deal), but what about more important Rx meds?

These links never say increase or decease, they just say "might be effected" and leave us guessing.

Guessed assumption is not much help LOL, If you can clarify that would be great.

Post Edited (astroman) : 12/10/2016 4:20:45 PM (GMT-7)

Posted 12/10/2016 11:00 PM (GMT 0)
I'm not G.H., but my take on your link is that the medications that taken with D-Limonene that breakdown in the liver quicker because of the Limonene will prevent the Limonene from being as effective.

Your link clearly said increase and decrease eventually, and gives examples under each.

Here is another similar link, which goes a little bit further. Other than what they mention, you probably need to check the specific medication you're concerned about, and see.

answers.webmd.com/answers/1188858/does-limonene-interact-with-any-other
Posted 12/10/2016 11:11 PM (GMT 0)
Oh...... yes, the last part said "Taking limonene along with medications that increase the breakdown of limonene in the liver might decrease the effects of limonene."

Guess I should re-word my concern/question.

Most people aren't concerned with what will happen to the D-Limonene.

If D-limonene's effectiveness is decreased, nothing bad will happen, just will need more D-limonene. If its increased, D-limonene has been tested safe up to 15,000 mg per day (that is a lot considering the gel tabs are 1000mg!). The most known side effect of increased D-limonene is more burping.

The concern is what could happen (increase/decrease effectiveness) to any certain Rx meds they are on - while taking D-limonene with them. Will the meds be increased or decreased is the question.

If nothing happens to the meds, then there is no thing to worry about :)

Post Edited (astroman) : 12/10/2016 4:24:12 PM (GMT-7)

Posted 12/11/2016 1:23 AM (GMT 0)
Hard to say how much effect it actually has but my opinion is that the interactions are overrated. The severe P450 reactions, the ones that kill people are figured out pretty quick. There are many P450 enzymes and these enzymes break down food too. It's not just medications that have an effect. The more meds you take the more potential issues you can have. I know of someone who killed himself by taking multiple meds (I think it was 5) that had P450 interactions. He intentionally tried to kill himself (with really high doses) and did not succeed at first. After a brief hospital stay, he was eating mashed potatoes the very next week when serotonin syndrome kicked in and caused a seizure. He aspirated the potatoes and died.

If you all knew of all of the drug interactions that are occurring between your meds, you would never take them. I think the benefit of D-Limonene greatly outweighs the risk. If you are on a narrow therapeutic window med like carbamazepine or paroxetine (where 8% of Caucasians don't even have the 2D6 isoenzyme), then it becomes more critical.
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