Somebody said...
MyD88-deficient mice harbored extremely high levels of B. burgdorferi in tissues when compared with wild-type littermates and greater amounts of spirochetes in tissues than TLR2-deficient mice. These findings suggest that, in addition to TLR2, other MyD88-dependent pathways play a significant role in the host defense to B. burgdorferi. MyD88(-/-) mice maintained the ability to produce Abs directed against B. burgdorferi. Partial clearance of spirochetes was evident in long term infection studies and immune sera from MyD88-deficient mice were able to protect naive mice from infection with B. burgdorferi. Thus, the acquired immune response appeared to be functional in MyD88(-/-) mice, and the inability to control spirochete numbers was due to a failure of cells involved in innate defenses. Although macrophages from MyD88(-/-) mice responded poorly to Borrelia sonicate in vitro, MyD88(-/-) mice still developed an inflammatory arthritis after infection with B. burgdorferi characterized by an influx of neutrophils and mononuclear cells.
TLRs are thought to utilize the adaptor molecule myeloid differentiation primary response 88 (MyD88). TLR2 responses to B. burgdorferi have been the most extensively studied as B. burgdorferi express a large number of triacylated lipoproteins that activate TLR2/1 heterodimers (1, 2, 5, 7–10). In murine models,
loss of MyD88 results in a greatly increased replication of the organism and up to several hundredfold increases in tissue numbers of bacteria (6, 11, 12). Stimulation with TLR2 specific lipopeptides was shown to lead to the activation of type I interferons and proinflammatory cytokines, such as IL-6, whose activation and release was dependent on endosomal acidification (23, 26). Localization of TLR2 signaling thus appears to shape downstream induction of cytokines, with TLR2-induced activation of type I interferons taking place solely from intracellular compartments. Keep in mind elevated IL-6 is associated with depression, anxeity, paranoia, obessive disorders, etc. It should be noted that the hosts innate immue responses are oftentimes the inducers of our symptoms. Of course, the infection itself is the root cause. Nevertheless, the continuing of TLR2 induction also acidifies the blood pH below normal (7.35), which is called acidemia.
So, it's markedly important to modulate IL-6, so we can function and heal outselves appropreiately as well as alkalize to normal PH levels. This can be down through various supplements. Keep in mind, sometimes heavy dosages of antibiotics are not always the right move, except in the case of severe neuroborreliosis. Many can and will supress our innate immune response, as well as chelate macro-minerals including magnesium. They are also anti-nutrient, so keep all this in mind and supplement with the vitamins and minerals that are chelated from these drugs.
Moroever, B. Burgdorferi manipulated the hosts immune system, increasing IL-10 an anti-inflammatory cytokine. Studies illustrated that during first stage infection IL-10 levels are raised from baseline, which suppresses hosts innate immune response to fight off infection. Keep in mind fighting the infection will always cause debilitating symptoms and herxes. Increased IL-10 levels from baseline in joint fluid of hosts infected with Lyme, had relatively zero joint pain but a SIGNIFICANTLY increased spirochete load compared to hosts with decreased IL-10 levels in joint fluid. This gives credence to the fact that TH1 immune response is likely the cause of joint related symptoms. This means that your body is fighting the infection, which is good.
Hence, LOW levels of IL-10 cytokine contributes to the increase in inflammatory cytokines, which as I've said can causes symptoms but help to clear the infection. To completely suppress the immune system with steroids, immune suppressing drugs and herbs we are inevitably leaving the door
open for a more desseminated CNS infection. Hence, Immune modulating and stimulating supplements, if we can handle them may be important.
_____________________________________________
(((Spirulina)))
-Two pilot studies (unblinded) using Spirulina at 400mg daily (but with a higher concentration of Braun lipoproteins, those found in gram-negative bacteria cell walls) noted that (((Natural Killer))) (NK) cell activity increased by 40% as assessed by tumor killing ability (one study) and mRNA production of NK cells increased by 37-55% (200mg and 400mg, respectively) after a week of supplementation! This is very important to note as this supplement in initial stages of infection can help to combat the first phase of anti-inflammatory host resposne caused by immune system manipulation from spirochete. In the most general definition, NK cells work by attacking foreign pathogens.
-A handful of studies on the subject do suggest that spirulina can increase natural killer (NK) cell activity in the body after a relatively low-dose ingestion
- In animals, the increase in NK cell activity appears to be mediated via Myeloid differentiation primary response gene (MyD88) which is in the TLR4 activation pathway, as abolishing this protein abolishes the NK activation seen with Spirulina.[145] Spirulina was also synergistic with a (((MyD88 inducer))), keep this in mind as MD88 deficent hosts have a MUCH higher concentration of spirochetes in tissue.
-The induction of NK cell activity may be non-selective mediated via toll-like receptors, as abolishment of either TLR2 or TLR4 does not diminish the NK enhancing activity of Spirulina but double-abolishment does.[145] Although TLR3-TICAM-1 can induce natural killer cell activation,[146] TICAM-1-/- mice do not appear to reduce the efficacy of Spirulina.[145]
-Spirulina appears to work via a TLR2/4 pathway that is dependent on MyD88, very similer to B, Burgdorferi, which is a TLR2 receptor agonist.
-Increases Neutrophils and Nitruc Oxide; secreted by macrophages which can kill spirochetes. Keep in mind that taking all these together can cause tremendous body herxes.
_____________________________________________
(((Reishi Mushroom))), Whole Fruiting Body Extracts, Mycileum does not cut it.
- Significant Increase in Natural killer cell content as well as activity in relatively small dosages over a few weeks. Modulated pro-inflammatory cytokines. This is good for modulating and stimulating the immune system when necessary.
_____________________________________________
(((Garlic)))
-Macrophage activation in response to bacterial infections and, when cooperating with Th1 cells, an increase in immunity. Elsewhere, garlic oil has been noted to increase IFN-γ when given to rats at 100mg/kg orally.
-Increased immunity and natural killer cell activity
-Nitruc Oxide increase
-Natural antibiotic
_____________________________________________
(((Glutathione, Whey concentrate))) Anything that has a good amount of the metabolite, L-cysteine; this includes garlic which has a sub-from of this.
-glutathione supplementation may be useful to augment nitric oxide boosters such as L-Citrulline, found in watermelon or L-Arginine. Again, works well to combat infection progression.
_____________________________________________
Basically a rant but I thought I'd share