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Lyme and babesia protocol

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Posted 3/17/2017 1:20 AM (GMT 0)
Don't forget the L-Arginine and milk thistle seed. Need the NO and the glutithione.
Posted 3/17/2017 12:07 PM (GMT 0)

OldSalty said...
Don't forget the L-Arginine and milk thistle seed. Need the NO and the glutithione.

You can't take Milk Thistle while you're on Mepron or Malarone.
Posted 3/17/2017 5:35 PM (GMT 0)

Mustard Seed said...

OldSalty said...
Don't forget the L-Arginine and milk thistle seed. Need the NO and the glutithione.

You can't take Milk Thistle while you're on Mepron or Malarone.

Thanks for the reminder, MS.


I have a homeopathic liver support - wonder if that's okay? (Pekana - apo-hepat)
Posted 3/17/2017 5:40 PM (GMT 0)
Interesting - I did put milk thistle with mepron in the Drug Interaction checker I use and it came up with no interactions - see below:


Drug List (Unsaved) Email | Print | Save | Create new list
milk thistle
Mepron (atovaquone)



Consumer
Professional
Major Moderate Minor Food Therapeutic Duplication
Interactions between your selected drugs
No results found - however, this does not necessarily mean no interactions exist. Always consult with your doctor or pharmacist.

Other drugs and diseases that your selected drugs interact with
milk thistle interacts with 2 other drugs.
Mepron (atovaquone) interacts with more than 30 other drugs and 2 diseases.
Interactions between your selected drugs and food
Moderate
atovaquone food
Applies to: Mepron (atovaquone)

Food significantly enhances the absorption of atovaquone. You should take each dose of atovaquone at the same time each day with a meal or a milky drink. If you receive enteral nutrition (tube feeding), take atovaquone with your feeding. Taking it on an empty stomach may lead to inadequate blood levels and reduced effectiveness of the medication. Talk to your doctor if you have questions or have difficulty taking atovaquone with food.

Switch to professional interaction data

Therapeutic duplication warnings
No therapeutic duplications were found for your selected drugs.
Posted 3/17/2017 5:41 PM (GMT 0)
Is it due to the cytochrome P450?
Posted 3/17/2017 7:16 PM (GMT 0)

Girlie said...
Is it due to the cytochrome P450?

I think it's a combination of that and the fact that as an antioxidant, it counteracts the mechanism in which atovaquone works.

Not 100% sure to be honest.

I find drug interaction checkers to not work so well with herbs, except for well known interactions like St. Johns Wort.
Posted 5/25/2017 2:49 AM (GMT 0)
Hi - this is the first time I am posting. I was diagnosed with babesia in Jan 2017. I think I was bitten by tick around august 2016 since I had flu symptoms. Had 10 days Amoxy 875 mg 2x per day for 10 days. Then actually diagnosed with Lyme nov 2016 and had doxy for 5 weeks. Doc thinks I may only have babs at this point. I was on malarone for 2.5 months , started feeling good, then ended up adding Zith. Feel like I went backwards a little. Doc wants me to up malarone amount but I read dr. R recommendations and 250/100. 2x per day should be adequate - has anyone gotten better not upping meds? How can one tell difference between side effects of meds and herx or disease? Also when I started zith, was also started on nystatin. Talked to someone and she said it is nystatin that makes someone feel foggy and dizzy - anyone have that experience? Thx!
Posted 5/25/2017 3:21 AM (GMT 0)
Welcome BabsPlanner.

250mg Malarone 2x a day is a good starting dose, but it's a fairly low dose of atovaquone overall.

For instance, Mepron (liquid atovaquone) is often started at 750mg 2x daily, so three times your current amount.

If you haven't had any improvement and your doctor wants you to up the dose, I probably would.

Also make sure you eat a bunch of fat with each dose for optimal absorbtion. 30-40 grams of fat. Otherwise the medication will just go straight through you.

You might get some more answers if you start your own new thread too, if no one comes up after me here.
Posted 5/25/2017 8:06 AM (GMT 0)
Welcome to our community, BabsPlanner.

I'm sorry you have Lyme disease, but glad you found us here.

I don't know enough about the Malarone to say whether or not an increase is required. Is your Dr. Lyme Literate?

And, as Mustard Seed said - you need to take the malarone with a good amount of fat each time for best absorption.

We do encourage our new members to read through the thread at the top of the page titled: "New to Lyme?..Start Here!" It's packed full of useful information.

I hope you stick around...read posts...ask questions, it's a great group of people - lots of support and knowledge here.
Posted 5/26/2017 3:05 AM (GMT 0)
I had a (barely) positive for Babesia through Igenex. My LLMD prescribed Malarone, and I just finished it after about 5.5 months. Months into the treatment, through research, I found out that many people recommend taking it with an antibiotic, so in hindsight, maybe I should have requested that. I did not.

I did not have many Babesia symptoms, so we were surprised by the positive test result. I did, however, have chills occasionally where I could not get warmed up no matter what I did.

Probably about 3-4 months into the treatment, these stopped, so I hope that means it's gone now.
Posted 5/26/2017 10:43 AM (GMT 0)
BabsPlanner, I have been taking malarone with zith for 4 months. I started out with 1 tablet twice a day for two months. I was in a constant herx. I then added an additional pill in the morning for another month and a half. Three weeks ago, I started taking malarone 2 pills twice a day.

After four months I am finally having some breaks with the constant crazy symptoms. This has been very rough on me. I believe I definitely needed the increased dosage. I am also pulsing artemisia with this protocol. Still very ill but more hopeful!
Posted 5/26/2017 3:13 PM (GMT 0)
Yes, A_Anne - LLMD's do prescribe an antibiotic to take with the Malarone.

Loutucky - I've been taking Mepron for almost 3 months now at the 1 tsp twice daily dose.
I'm still 'feeling' it...so wasn't going to increase.

Were you still herxing from the lower dose..when you upped it to 2 pills twice a day?

I'm wondering if I should be increasing my Mepron to 2 tsp twice daily...even though I am herxing with the lower dose.
Posted 5/26/2017 3:35 PM (GMT 0)
Girlie, I was definitely herxing still when I was only taking 2 tablets a day. The herxing got worse on 3 tablets and then 4 tablets. However, I am seeing some relief finally on the 4 tablets. Still herxing badly but I am having improvement in two areas. My air hunger/tight chest is better and my anxiety is lower.

Headpressure, stiff neck, headache, fever and muscle pain are still raging.

Remember Mepron is much stronger than Malarone. With 4 tablets of Malarone, I am only getting 1000mg of atovaquone per day. Your two teaspoons are more than that I think. I do get 400mg of proguanil with malarone but I think the atovaquone is stronger.
Posted 5/26/2017 3:57 PM (GMT 0)
two tsp is 1500 mg atovaquone. So yes, you're right about that.
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