My experience is as insomniaaa suggested -- smaller doses of melatonin work better.
After trial-and-error, here's what helps me stay asleep:
1. Low-Dose Naltrexone (3.0 mg at bedtime)
2.
Deep Sleep (One caplet at bedtime)
3.
Low-Dose, Extended-Release Melatonin (One 300 mcg tablet at bedtime)
According to Richard Wurtman, MD at the MIT Department of Brain and Cognitive Sciences, the optimal dose of Melatonin is pretty small -- around 300 micrograms.
http://wurtmanlab.mit.edu/projects<--- Begin Quote --->
Dr. Richard J. Wurtman, a distinguished professor of neuropharmacology at the Massachusetts Institute of Technology, said older people often have trouble getting to sleep because the pineal gland, where melatonin is produced, "gets calcified with age." Taking a little bit of the hormone makes up for the pineal gland's weakness, he explained.
In 2001, Wurtman and his colleagues published a study in the Journal of Clinical Endocrinology and Metabolism that suggested that small doses of melatonin -- no more than 0.3 milligrams -- could help older people conquer insomnia.
But it's got to be just this little bit, Wurtman said, because too much melatonin overwhelms and deactivates receptors that transfer the hormone into cells.
Wurtman noted that the Alberta study used doses as high a 6 milligrams. "They are giving 20 times the correct dose," he said. "The higher the dose we gave, the lower the response we got."
Most of the melatonin products now on the market give similar overdoses, Wurtman said. The result: "Your insomnia gets worse after a while," he said. "What you need is low doses that raise blood levels to where they were when they were young. It's the equivalent of hormone replacement therapy for women."<--- End Quote --->
My OPINION is that taking low doses of Melatonin is likely more safe than not. I'd be more worried about
taking prescript
ion sleep aids indefinitely. However, that's between you and your Doctor. You DO need to sleep, obviously!