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Zithro once a week

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Lyme Disease
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Posted 5/21/2019 7:16 PM (GMT 0)
Hello,

Looking for feedback and support on this. I seem to only tolerate zithro 250mg once a week, if not two weeks. It seems the only abx that i tolerate that hits my Bart/Babs hard. I am also taking cefixime along with it. Should i be afraid of resistance building with this schedule. I thi nk after one week zithro still in blood, but i might have it more time since the everybody is different. Thank you.
Posted 5/21/2019 7:40 PM (GMT 0)

Somebody said...
Following a single dose of 500 mg, the apparent terminal elimination half-life of azithromycin is 68 hours. Biliary excretion of azithromycin, predominantly unchanged, is a major route of elimination. Over the course of a week, about 6% of the administered dose appears as unchanged drug in urine.

so after a week only 6% is left, however there is still quite a bit left even 3 or 4 days after you take it.

Also bart feeds on amino acids, NOT glucose so its weird like that.

https://www.ncbi.nlm.nih.gov/pmc/articles/pmc348914/

According to what I read Bart replicates slowly and takes 5 - 7 days to form a colony so its possible once a week could still be effective, although I have no idea how resistance might work.
Posted 5/21/2019 8:22 PM (GMT 0)
Thank you Lapis, i have to try. Took 250mg last saturday suffered hard until today. But its unpredictable, i might suffer today again. But after the dose rash appeared Next morning, jerks went wild, and my trigeminal pain increased ten fold. Going to try it next saturday or sunday again.
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