Disulfiram - Part 1

alldaychemist took my visa credit card, but before I could only pay via bitcoin (I used coinbase), so it has changed.

250mg disulfiram apparently isn't a controlled substance. I'm not sure if that means if you need a prescription or not. I'm not sure if a pharmacy would just give it to you, but why pay $700 when you pay $30 online.

of course you shouldn't use any alcohol based tenures. I wouldn't take any prescription drugs with it myself. But saying that, even if you could take tintures or other lyme meds, - lets say the tintures were water based, to me they are 1% effective as my one week experience with disulfiram. I've probably made an entire month+ progress with just one week.

there are interactions with disulfiram, you should google and research them. if you have liver problems, or suspect this, you should definitely get a test from your doctor. I did not and I am fine.

I don't think you should start off at 250mg (one pill) a day. The post mentioning Dr. Liegner starting off at low dosage -- 62.5mg, every three days, is probably best. I did 1/4 of a 250mg pill for a day, waited 48 hours, it hit a bunch of stuff, took it again. It was in the range of 50-75mg (1/4 pill). The last two nights I have done 1/2 pill, 125mg-ish. In the last 8 days I have only _3_ pills. I will start 250mg tomorrow night!

I feel incredible. Given I was already at "95%", it is hitting things I didn't know I had. I having no issues EXCEPT I can't sleep. I feel more than better. I think this has to do with the large Vitamin B3 non-niacin niacinamide -- 2 to 3 grams a day and L-2G/day Argintine. I'm not sure if it is either or, or both, or the Zinc/Selenium/Magnesium Sulfate/Potassium-Iodine/Table salt and fasting every other day or at least 18 hours, but I am feeling absolutely W O N D E R F U L.

You have to note that disulfiram has a long half life - 120 hours. What this means is if you take 50mg, in 120 hours ( 5 days) you will have half left -- so 25mg. This means this:
day 1 - take 50mg, you have 50mg in your body
day 2 - take 50mg, you have 100mg
day 3 - take 50mg, you have 150mg
day 4 - take 50mg, you have 200mg
day 5 - take 50mg, you have 50 + 50 + 50 + 50 + HALF of day 1's dose or 25 or _225mg_ in your body

of course this is a trivialized version of events it isn't going to magically be 50 and suddenly 25mg on day 5, it will be in between. And if you break the pill in 1/4 and it is the short side ... 40mg or a bigger chunk, ... 75mg, etc.

because of the large half life -- you "load up" and accumulate. When it hits something or you feel bad, skip a day -- it's still there and half of it will be gone in 5 more days. For me I ran out of dopamine on day 5 and felt depressed - but I knew it was chemical (I was out of dopamine because you can't be happy 24hr 5+ straight) and wasn't real. I'm very very happy and just waited and it lifted

that being said, there appears to be a threshold-delayed-die-off effect with killing lyme. It'll hit something small and up front in the beginning, you'll feel fine for 3 days.. or a week, or two weeks, then all the sudden BAM! somewhere something finally gave in and it'll feel that you hit something big or hard, you might feel bad for 3 days. Then after this you will feel great because you've reduce the lyme load. This happened to me on other medications -- like Amoxicillin or Ivermectin, you would get this delayed effect. I have not experienced it yet with disulfiram. I'm pretty sure everyone knows about this or experienced it if you've done treatment for a long time -- just saying. But my point is the "Load Up" with the 120 hour half life you must pay attention to this threshold-delayed-die-off effect.

Given this medication is very effective I to iterate: I really think you should start it at very low dosage -- 50 or 75mg, wait 3 days, whoever posted this advice: Thank you

For me I think it was the Vitamin B3 niacinamide that helped me the most with Disulfiram. It appears to convert the die-off into a morphine like substance, giving a long term 4-5 day euphoria. Don't forget to enjoy your free morphine trip.

If this really is a bio-weapon and if this die-off-niacinamide-to-morphine link can be proven, then this is a major flaw as a weapon. Because infected soliders could just take disulfiram and B3 and be jacked up on morphine-like substances, unable to sleep -- basically become super soliders. Whoopts, ...

Post Edited (oregonhay) : 9/1/2019 11:12:55 AM (GMT-6)

oregonhay said...
For me I think it was the Vitamin B3 niacinamide that helped me the most with Disulfiram. It appears to convert the die-off into a morphine like substance, giving a long term 4-5 day euphoria. Don't forget to enjoy your free morphine trip.

If this really is a bio-weapon and if this die-off-niacinamide-to-morphine link can be proven, then this is a major flaw as a weapon. Because infected soliders could just take disulfiram and B3 and be jacked up on morphine-like substances, unable to sleep -- basically become super soliders. Whoopts, ...

I got this effect from valproate, and I really didn't like it at all. It messed with my REM sleep and caused constipation, although it did somewhat reduce the herx pain.

Valproate does not have any intrinsic opioid activity, however it interferes with morphine tolerance by blocking GSK3β and possibly by blocking histone deacetylase also. See https://www.ncbi.nlm.nih.gov/pubmed/20816918

Perhaps disulfiram inhibits GSK3β similar to valproate?

It's unclear why niacinamide would have such an effect. Morphine biosynthesis in humans starts with tyrosine or dopamine, not niacinamide (see https://en.wikipedia.org/wiki/morphine#human_biosynthesis).

Brab8878 said...
1 week update from me. VERY optimistic about it.

I don’t have typical herx/ flares. Everything is always in my brain with changes in pressure, brain fatigue, mood, being able to socialize and tolerate stimulation ie TV etc

Hadn’t watched tv for a few months and have been able to watch for a few hours this week. Finally getting out of my room for a few hours a day.

Overall just feel a lot more confortable and not crawling out my skin

Not sure if anyone else gets this but it’s almost like I can feel it killing stuff in my head. My head pressure has been changing, stuff feels like it drains from my head when I go to the bathroom.

All good signs and stuff I’ve very rarely felt before. Finally feels like my head is clearing.

Still a long ways to go and I notoriously do well in the beginning with treatment ( not like this though) but this is the most optimistic I’ve been with something in forever.

Hey buddy, update?

niacinamide?

nicatinamide?

niacin?

does it matter?

Hi guys! Been making great progress on my end! baseline symptoms seem to continually be improving, and mind feels sharp and clear (best it's felt in 10+ years!).

I'm still getting some flare on treatment (been taking full dose 500mg/daily for close to 4 weeks now). The flare is mostly fatigue, and some residual headache but it has been downcycling in severity as I work my way thru treatment.

This last week I've had moments where my energy felt really really good, which is hugely encouraging (been very fatigued throughout treatment, I think the DSF is causing a ton of fatigue flare symptoms, I ascribe to flare because it patterns with all my other neuro symptoms as well). Still have to be careful in how hard I push myself, given treatment seems to still be creating die-off, which means my margins for pushing my body are still a bit thin.

Brab8878: That sounds encouraging! it also sounds like a lot of patients taking DSF experience strong fatigue. For most of us it seems to be flare-related. Always hard to say with 100% certainty, but that's my vibe for my own case and quite a few other patients are reading it that way in their own. That's great news about that symptom improving, hopefully a very good sign

Steelogreens: Have you started DSF? keep us posted if you do!

Sebreg, how long did it take you to get up to 500 mg daily? Doctor has me on 125 mg every other day now.

The difference could be that disulfiram has a half life of 60-120 hours and is not an antibiotic so it could work better in humans than a antibiotic cocktail.

Time will tell I guess.

sodapopinski said...
For what it's worth, Columbia University is just beginning a clinical trial of disulfiram in people with Lyme: https://clinicaltrials.gov/ct2/show/NCT03891667

It's a small trial with 24 patients enrolled. They're looking at safety in this first study, as well as the optimal length of treatment. A subsequent study (presumably with more people enrolled) will look at effectiveness. The first study is supposed to wrap up in March 2021.

Until then, I'll be hitting "refresh" on this conversation regularly, and will be eager to hear continued reports from those who are trying it. Sounds promising so far!

Hey sodapopinski (love your name) - welcome to our forum.