Opinions please

I recently had iGENEX testing for Lyme and coinfections. It all came back negative. I was surprised but relieved. Now I’m hesitant.
As I look closer I see that the test for IgM Lyme (immunoblot for B. burgdorferi)
Bands 31 and 41 were “indeterminate”

I have so many symptoms of neurological Lyme. Balance, visual problems, tingling scalp, memory problems, joint pain, ridiculous fatigue, etc. I also have TMD problems that I am treating. There is some overlap of symptoms with balance and pain between Lyme and TMD.

My question for you Lyme veterans:
Would an indeterminate for bands 31 and 41 give you pause? Would you dig deeper?


I recently tested positive for EBV reactivation IgM and all three IgGs are positive.

Hi, while on its own an indeterminate 31 and 41 wouldn't be huge alarm bells, their potential import is increased given your constellation of neuro symptoms imo. The clinical picture adds weight to those results (and it's really unfortunate we have to rely on this flawed 1950s testing tech to read the tea leaves), but that's the way the testing paradigm currently is. 31 is specific for borrelia, which I think may be a good clue coupled with the symptoms. It's not slam-dunk, but merits strong consideration.

Could you revisit the antimicrobial challenge? I've always liked that tool as an indirect method of getting more information. I understand not wanting to poke the bear. But if you take antimicrobials at strong enough dosage, and in fact engender a flare, at least you give yourself a bit more indirect confirmation that you are dealing with an underlying infection(s). Then you can always improvise the treatments to a level that is manageable.

band 41 is flagella detected ... no good spirochetes have tails ....and u dont have yersina or syphilis (u'd know) so the only obvious choice is there is a systemic borrelia infection suppressing your immune response and causing symptoms... welcome ..sorry