High B12 levels and MTHFR mutation

Canfossi

Regular Member

Joined : Oct 2019

Posts : 151

Posted 5/18/2020 4:22 PM (GMT 0)

I know there are other causes of high B12 levels, but I am reading that a number of people with Lyme disease have high B12. Is it related to the MTHFR mutation where the body can't detox well enough and the heavy metals and B12 levels rise? I know you can't change genetics. What can she take to reduce the high B12 levels, methyl B12, anything else? Can this mutation be tested for with bloodwork? My mom is going to talk to her LLMD this week. Any advice would be greatly appreciated beforehand. Thanks!

Post Edited (Canfossi) : 5/18/2020 10:30:13 AM (GMT-6)

Korissa

Regular Member

Joined : Oct 2006

Posts : 442

Posted 5/20/2020 5:01 PM (GMT 0)

I had abnormally high b-12 a while back and learned I dont handle methyl groups well according to genetics.

Melatonin is methyl and so I dont take it or methylcobalamin (b-12).

I was takining adenosyl/hydroxycobalamin instead but have been out of it for months. Forget to order and maybe its partly the cause of my fatigue.

wish I could get tested for b-12 levels.

Village Crazy Lady

Regular Member

Joined : Feb 2017

Posts : 459

Posted 5/21/2020 5:05 AM (GMT 0)

Hey
I have single parent 677 and 1298 MTHFR mutations. I’m told to take methylfolate 15 for the rest of my life. Avoid folic because we can’t convert it to folate.
The methylfolate is what converts serum blood b-12 to cellular usable b12. These also determine how well your detox system is working.
I always have extremely high serum b12 so I just use a little less of my methylcobalamin b12 shots and add more methylfolate to boost the process into the cellular form.
Good luck
VCL

Georgia Hunter

Veteran Member

Joined : May 2012

Posts : 2688

Posted 5/21/2020 8:25 AM (GMT 0)

Korissa, good post.

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