Most of us on this forum have the MTR and MTRR heterozygous mutations. They are often indicative of pathogenic influence. IMO, NAD+ alterations from elevated oxidative stress are what lead to these. They slow the pathway but often aren't overly problematic.
The CBS699T and COMT often go hand in hand. As excess sulfur builds up from methionine ingestion, the body flips this CBS gene to improve glutathione production and help transulfuration. A lot of nutrient wasting has occurred and Vitamin B6 and molybdenum for the transulfuration pathway which begins with CBS. Both B6 and molybdenum often need higher levels but supplementing them can be problematic and increase issues. Any supplementation must be low and slow.
Check BHMT 1,2,4 and 8 for mutations. Having these genes intact make things much better. Homozygous mutations on these genes with CBS causes more issues.
Multiple avenues can be taken for improvement, but which one I can't say. A reduction of sulfur intake would be a recommendation. That may include SAMe too. This could lead to methyl group availability issues so Betaine might be an option. Eating more foods high in molybdenum but low in sulfur would be a recommendation. These foods would be alkaline and not contain palmitic acid. Foods rich in the Vitamin B-6 and low in sulfur would be a recommendation.
Tryptophan availability would be a concern now and especially if the diet is altered to the recommendations above. Niacin may be required to help offset this problem. I've seen higher Thiamine levels needed as well.
Basically, we have 100 little fires that need putting out and this will stop putting out those fires. When you put out 5 fires, another fire will pop up somewhere else. Sometimes, the fires that pop up are bigger than the fires you just put out. Finding someone who can help guide you that is knowledgeable about
Lyme is very important.
Post Edited (Georgia Hunter) : 6/24/2021 6:19:27 AM (GMT-6)