these are all good questions WBF - but i think the issue is most of this stuff is being done on a trial and error basis in the clinic - with little actual research into what is really going on in Bartonella / Babesia patients.
sounds like Dr M is starting to do that - perhaps with Ed Breischwerdts and Dr Maggi and maybe T-Lab as they are all connected - would be good to see or hear their presentation that Dr MR was referring to in his video
does any one know if that is available - as perhaps it has more info ?
the only other sources i know of are
- on the breaking down bartonella group - some patients of Dr M are there - and they are using mostly Buloke singly ( not with other enzymes ) as far as i could tell
- the Townsend letter i linked to which advocates the use of any or several of these enzymes as critical to treatment - included in th article were nattokinase, serrapeptase, lumbrokinase / Buloke and even bromelain and papayain - none were given real preference or hierarchy as i recall - but is from 2016 - so a few years old
the other issue that might be at play is that different people may tolerate different enzymes better than others
my gut reacts to nattokinase with pain and gurgling and other disturbances , but as far as i recall i could take bromelain more easily
Dr AC also wrote that some people need to start on tiny doses - so perhaps there is a role here for the supposedly weaker fibrinolytics in the protocol to begin with, and the more powerful one later
the other issue that might be at play is that fibrin is not really a single substance - but is a protein( it may even be a group of proteins) that may be soluble or deposited into a solid or semi solid gel like substance - and i think i read some time ago that some enzymes are good at breaking up the already deposited stuff and some only really keep the soluble stuff from laying down more.
ref clotting testing - i have had tests for Hughe's syndrome ( aka "sticky blood" or anti-phospholipid syndrome) which involved some clotting factor tests ( its a rather scary auto-immune condition that causes spontaneous clotting, stoke etc of unknown origin - but i suspect intra red blood cell stealth infection from Bart is the likely cause in most cases)
there are a huge array of chemical and mechanism involved in the clotting response.
one of the tests i had was called the Lupus Anti-Coagulant screen
some of which were outside normal range - but the interpretation says "no anomalies detected despite one maker being outside the reference range and another on the high limit -
no anti-cardio leptin antibodies - so that was written off as a dead end
i have since learned that high prothombin clotting times are associated with clotting disorders like hughes syndrome - but i suspect in my case infection is driving the process.
i will include the results below in case its of any help
DIL. RUSSELS VIPER VENOM TEST
DRVVT INTERPRETATION *
Lupus anticoagulant screen: No abnormality detected.
Clotting screening test
One stage prothrombin time 15 s [11.0 - 14.0]
Above high reference limit
Partial thromboplastin time activated 37 s [24.0 - 37.0]
Fibrinogen level 2.32 g/L [1.5 - 4.5]
BTW - i have very poor capillary refill on my legs when standing that is worse when my symptoms are flaring and improves when my overall health improves. this is a very simple test of microcirculation ( related to clotting / blood stickiness ) used by hands on clinical doctors in the days before lab testing. i suspect most Bart patients will have the same.
Post Edited (Garzie) : 10/28/2021 4:42:10 AM (GMT-6)