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Peptides BPC-157, TB4 and LL-37

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Posted 11/21/2023 9:53 AM (GMT 0)
Hello,

I have searched in the r/peptide reddit and i have found some stuff that might be helpfull for regeneration and immune system support.

BPC-157 = Regeneration
TB4 = Regeneration and Immune Support
LL-37 = Strong Immune System Support, adverse effects more likely.

I think about trying bpc-157 and tb4... Has anybody heared of peptides and tried them?

Greetz
Posted 11/21/2023 10:41 AM (GMT 0)
one of our longstanding members here RainyCloud has delved deep into peptides - and tried several of them i believe - he may join the topic

BPC-157 seems to be one of the better known ones in lyme circles
some LLMD's advocate its use - eg Dr MR
Posted 11/21/2023 3:36 PM (GMT 0)
BPC gave me vertigo that subsided after stopping and fully went away over 1-2 weeks after.

I think that’s a rarer reaction but made me stop.

I’ve been wanting to try KPV and cerebrolysin.
Posted 11/21/2023 6:27 PM (GMT 0)
I forgot about peptides, but remember there used to be occasional posts here about them.

(I should research if any peptides help out with Primary Immunodeficiency).
Posted 11/21/2023 6:29 PM (GMT 0)
i have just ordered bpc-157 and endothelin.
Posted 11/21/2023 6:31 PM (GMT 0)
Dr MR has a page on them

https://www.treatlyme.net/guide/repair-restore-peptides-lyme-mold-toxins
Posted 11/21/2023 6:36 PM (GMT 0)
BPC sounds like a wonder drug for Lyme/Bart

would like to hear more personal experiences - in terms of how much it helped - what doses were needed and if the gains were maintained after discontinuing the supplement

Dr MR said...
Start with BPC-157
A good place to start a peptide support program is to take BPC-157 500 mcg 1 pill 2 times a day. Over a month, a person can increase this up to 3 pills 2 times a day if needed, but usually 1 pill 2 times a day is enough.

I am finding this very helpful to repair tissues that are hurt by the inflammation of Lyme and mold toxicity illness. This is helping with joint area pains, nerve pain and numbness, and even brain function. In addition to repairing tissue, BPC-157 improves germ fighting as it balances healthy immune function between the germ-fighting Th1 cells and the autoimmune and allergy Th2 cells. Because BPC-157 supports mitochondrial function, this can help with energy. For those with mast cell activation, it may provide benefits, too. BPC-157 is also useful in repairing leaky gut syndrome and intestinal dysfunction.

Posted 11/21/2023 6:55 PM (GMT 0)
"..........BPC-157 is also useful in repairing leaky gut syndrome and intestinal dysfunction......"

hmmm, good to know. On my research list.

Is there a well known Peptide "seller"? Any brands better than others?

Post Edited (astroman) : 11/21/2023 11:27:58 AM (GMT-8)

Posted 11/21/2023 7:41 PM (GMT 0)
i think we need Rainy - he has used several if i recall correctly

i think Dr MR sells BPC on his site though
Posted 11/21/2023 9:00 PM (GMT 0)
there is a big discussion if bpc needs to be injected or not.
most peptides need to be injected in fat tissue or muscle tissue and cant be resorbed via oral route.

bpc-157 is said to be available orally as one of very few peptides wich actually do, so the hurdle is a bit higher for that one but can be managed very well if you disinfect correctly etc etc.

i have never injected anything in my life myself so testing LL-37 for example wich has 0 oral bioavailability would be very big step for me.

enthodelin is offered as nasal spray so it seems it can be absorbed via nose tissue wich makes it easier also.

lets see what rainy says. lots of redditors claim it helped their cfs/inflammation wich can be very similar to lyme in symptoms.
Posted 11/22/2023 2:39 AM (GMT 0)
I tried BPC-157 for two weeks. It gave me more energy, it lifted my brain fog, less pain. I think it really helped in a lot of ways.

But... it also made my skin itchy, made my nose bleed every day & possibly gave me a cavernoma. So be mindful, it grows blood vessels. It can grow the wrong things.


If I wasn't scared of growing that cavernoma even more, I would still use it.

I used the oral version from Dr MR site.
Posted 11/22/2023 2:26 PM (GMT 0)

loski01 said...
BPC gave me vertigo that subsided after stopping and fully went away over 1-2 weeks after.

I think that’s a rarer reaction but made me stop.

I’ve been wanting to try KPV and cerebrolysin.

Do you know by any Chance If kpv has to be injected? I heared kpv orally only has effect in stomach and gut healing but injecting is needed for General Treatment.
Posted 11/22/2023 3:45 PM (GMT 0)
As far as injecting peptides, I'm guessing there are suggested injection points/areas?

In the past, I had to do my own morning injections of a specific blood thinner daily for one week. It was in the outer stomach fat (we all have some). If I had to inject in a vein, no way could I do it.

Procedure:
I was instructed/shown to inject specifically in the outer layer of fat over the stomach and was more mentally difficult than physically. Its done seated, and naturally a little hunched forward so you can pull the fat layer away from the muscles as best you can. It was easy. The less belly fat one has, the more careful/accurate you need to be. Fit/skinny people with less than 1" of belly fat have less to aim into. You inject more at an angle vs straight in at 90 degrees (less likely to go too deep that way).
Posted 11/22/2023 5:02 PM (GMT 0)

BlazerGermany said...

Do you know by any Chance If kpv has to be injected? I heared kpv orally only has effect in stomach and gut healing but injecting is needed for General Treatment.

I’ve heard both. Integrative peptides suggests they formulate for systemic absorption or something of the sorts. And I’ve heard the same for BPC that method of consumption doesn’t matter. I’ve also heard certain peptides breakdown easier in the gut vs others.

But there’s also people who suggest like KPV injection for systemic inflammation and oral for gut. Similarly again with BPC for specific injuries (injection) and oral for gut etc.

Personally I feel like the same logic as any other substance applies here, as the argument for injection is that stomach acid degrades the peptide = reduced systemic absorption - which could apply to anything else you take orally. Meaning I’m inclined to believe the bpc I took orally had a greater effect than just GI stuff as I developed vertigo and noticed changes in responses to things like caffeine etc.

Someone in a Facebook group mentioned they take KPV orally from the injectable form and that it was a lot cheaper that way(vs other brands) and worked fine.

On a slightly separate note there seems to be more positive buzz around melanotan 2 vs KPV even though they attempt to hit a similar pathway without some of the tanning side effect.

Post Edited (loski01) : 11/22/2023 9:05:36 AM (GMT-8)

Posted 11/22/2023 5:49 PM (GMT 0)

Vimzor said...
I tried BPC-157 for two weeks. It gave me more energy, it lifted my brain fog, less pain. I think it really helped in a lot of ways.

But... it also made my skin itchy, made my nose bleed every day & possibly gave me a cavernoma. So be mindful, it grows blood vessels. It can grow the wrong things.


If I wasn't scared of growing that cavernoma even more, I would still use it.

I used the oral version from Dr MR site.

thanks for the feedback

growing blood vessels seems like not such a good thing in tick born illnesses

but then again cavernoma are usually a form of angioma - which bartonella is well known for causing on its own - so it seems kind of hard to know if it was bart that caused it or the peptide - or a combination of the two

peptides seem tricky
so much promise - but also more than a few reports of adverse events
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