Hi, I also notice that if you don't take your medication on time it can cause on and off fluctuations through out the day more often. If i take my medication on time i tend to have a smoother day. My medication takes about a hour to kick in, sometimes i have to go and lay down and wait for them to kick in. I too can tell when my medicatiion is getting to the next dose and if i'm late taking it; it takes even longer for me to kick in. So, it is vital that you stick to the timing of your medication if you want to in control and not the PD!!!! Also, i find it depends our active you have been during the day. It's best to pace yourself than try to do every thing in one go, do you agree? Take care xx miss cutie xx