Pomegranate Juice Delays PSA Doubling

Sorry if this may be a rehash, but I did a search and didn't find anything on the forum. I'm not scheduled for my first post-op PSA until the 19th of March, but I'm hoping for the best.


The links are to a study that tends to indicate pomegranate juice may significantly extend the time it takes for PSA to double. The study was on 48 men who had already undergone treatment and whose PSA was rising. I know 48 men is hardly a trend, but I thought it was worth mentioning. Pomegranate also seems to do well with cardiovascular health and breast cancer, but I did not include those links, you can Google them easily. Provided FYI.



Cheers,



John




http://clincancerres.aacrjournals.org/content/12/13/4018.abstract



http://www.worldhealth.net/news/pomegranate_suppresses_prostate_cancer_g/



UCLA Clinical Trial:http://urology.ucla.edu/body.cfm?id=112


Links to older stories that also supported pomegranate juice’s qualities:



http://prostatecancerinfolink.net/2008/10/16/of-prostate-cancer-and-pomegranates/



http://www.webmd.com/prostate-cancer/news/20090426/pomegranate-juice-may-slow-prostate-cancer



http://www.sciencedaily.com/releases/2007/09/070924095856.htm



http://www.sciencedaily.com/releases/2006/07/060702084515.htm



http://news.healingwell.com/index.php?p=news1&id=528142

http://www.sciencedaily.com/releases/2005/10/051002120002.htm

I just wish I like the taste of the stuff, personally, I find it dreadful, even when mixed with other juices.

There was a local study here in Michigan between a few hospitals that sponsord these limited testings, but even among patients subdivided into HRPCa (refractive patients) and the norm PCa group patients a benefit was measured in months or longer depending upon the group and the things they ate. They did slow down doubling time substantially, so something is in the proof of this pudding (lol).
Things used were: soy, tomatoes, bright colored fruits (lycopenes).
So no down side to eating such things and maybe a nice plus side. I saw this presentation maybe 2 yrs. ago or more, but it was worth hearing about, it was for a PCa support group meeting.

Hi guys i tried the acca juice for 6 months at $38.00 a quart bottle i had no results that stuffwas suppose to out do everything on the market so much for that it did't work. Tomatoes have lacpione which does help in the fight, i do drink soy milk the chocolate.
Deerhunter!

Well, looking at one of the articles, human prostate cancer tumors grew slower in mice being fed pomegranate juice. Seems as if it might not just be the PSA, then...

Purgatory said...
...once the cow is out of the barn, the juice and other dietary changes aren't going to directly help any existing cancer situation.

David, once you've got prostate cancer, pomegranate juice won't reverse it.  If that's what "they" meant, then "they" are absolutely correct.  I would guess that's what they meant when then said "once the cow is out of the barn." 

But the really great news is that for those of us (like you and me) who have had either surgery or radiation (or both), Pomegranate juice has been shown to slow the further progression of prostate cancer (if any still exists within us).  Not stop it, but slow it.  There's a lot of guys who are in the same boat of wanting to slow the growth of PC after primary treatment (or while on AS).

Here's the actual titles of the first 3 links provided by defender3.

• Phase II Study of Pomegranate Juice for Men with Rising Prostate-Specific Antigen following Surgery or Radiation for Prostate Cancer
• Pomegranate suppresses prostate cancer genes
• Prostate Cancer: Clinical Trial of pomegranate liquid extract for men with rising PSA after primary treatment.

Like your doctors have said, it won't cure PC, but it is likely to slow the progression.  Try it if you'd like to stack some of the odds in your favor.

 

 

medved said...
Dr. Strum suggested that the tablets could be a good idea, since he likes the idea of pomegrante juice, but the sugar is a downside.

Medved, when I first read your sentence, I misinterpreted it.  Then I re-read it and recognized that it could be interperted two opposite ways. 

Just for clarity, I think that this is another way of saying the same thing:  Pomegranate extract provides the same benefit with less sugar.

 

 

keysailfisher said...
Is it true that Pomegranate juice and cholesterol medicine should not be taking together?

Neal

Neal, as innocent as the intent of that question may have been, it seems like you are asking a question that a doctor or pharmacist should answer...I am neither.

Nonetheless, we do both have access to www.pubmed.com which is an online, free library of medical publications.  I did a quick search of the terms "pomegranate AND cholesterol" and found 20 hits.  I just scanned the titles, but didn't find anything that seemed to imply a conflict between the two.  In fact, one was titled "Cholesterol-lowering effect of concentrated pomegranate juice consumption in type II diabetic patients with hyperlipidemia."

If you are on cholesterol meds and are concerned, probably worth a chat with your local phamacist.  Hope that helps...

zufus said...

There was a local study here in Michigan between a few hospitals that sponsord these limited testings, but even among patients subdivided into HRPCa (refractive patients) and the norm PCa group patients a benefit was measured in months or longer depending upon the group and the things they ate. They did slow down doubling time substaintly, so something is in the proof of this pudding (lol).
Things used were: soy, tomatoes, bright colored fruits (lycopenes).
So no down side to eating such things and maybe a nice plus side. I saw this presentation maybe 2 yrs. ago or more, but it was worth hearing about, it was for a PCa support group meeting.

I believe one of the studies showed doubling time increased to 54 months.

FYI,

For the cholestorel drugs like simvastatin,   do not intake any grapefruit juice or products as they cause interference.   Did not mention pomegranite juice in my instructions.

pasayten

FYI,

April 26, 2009 -- Drinking 8 ounces of pomegranate juice daily may slow the progression of localized prostate cancer ( prostate cancer that hasn't spread), a new study shows.

http://www.webmd.com/prostate-cancer/news/20090426/pomegranate-juice-may-slow-prostate-cancer

P.S.

Five of the six researchers who conducted the study disclose ties to POM Wonderful, which makes the pomegranate juice used in the study.

 

 

pasayten

 

Im patient
I hope those tests on the mice were right.

I don't wish to be a pessimist or spoil-sport here, but do these chemicals in the juices and fruits mentioned actually do anything to the cancer. It occurs to me that that could just be doing something to the way the cancer produces PSA or to the speed that the body breaks it down.

And with regard to lycopene in tomatoes etc this is appartantly one area where the tinned product is better than the fresh one. And tomato paste/puree is meant to be even richer in lycopene (not lacpione.)
see:
www.healthcastle.com/lycopene-prostatecancer.shtml

There's no harm in a good diet so I'm still happy to eat and drink this kind of stuff. (In moderation) but 10 servings of tomatoes a day seems a bit too much

I can't find pure pommy juice in my supermarket but bought a juice that contains pommy, plus raspberry, apple and blackcurrant, 12.5% total sugars and quite acidic it also contaions added sugar.

Also got another juice that contains mixture of acai, apple, grape, cherry, passionfruit and lemon total of 11.5% sugar.

(both these drinks have added Vit C and Vit E and are made from concentrate. They both cost €1.97 a litre and have to be kept refrigerated)

The juices I've been drinking in the past only contain 8.5% sugar, so maybe I'll end up seeing les of my uro and more of my dentist.

Alfred

Pubmed had this item too from 2002

www.ncbi.nlm.nih.gov/pubmed/12424330