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Welcome to HW.

I, and several other guys, use what I call a pre-plump method to ensure successful injections. It begins with a penis pump, if you have one, and a penis ring. Using the pump, obtain a partial- maybe 30%- erection and apply the ring. This engorges the penis with blood, opening the cavernous cavities and filling them with blood. Then inject into this expanded cavity. Imagine injecting into an uninflated balloon, and putting the drug into the inside, versus injecting into a partially inflated one. That's what is being accomplished with this method. When injecting, you can easily tell when the needle point enters the cavity, as the resistance will drop and the needle will feel like it has 'fallen' into it. Inject and very lightly massage the penis, the purpose is to spread the drug around and ensure optimium adsorption of the drug. Keeping the ring on for 3 or 4 minutes holds the blood (and drug) inside and lets it have the best chance of being adsorbed. Continue to gently massage the penis and the drug around for 3 to 4 minutes, then remove the ring- the blood will most likely run back out of the penis, until the erection begins. You should get the drug induced erection in 5 minutes or so. Most of us who use this method find we can use much less drug, we can control results more consistently from one time to the next and reduce the chance of priaprisms.

I used the method that James described, except no pumping, just constriction. I found that three minutes of constriction after injection was enough.

thanks for great advice! I will order a pump and ring today...

would a longer needle 1/2" vs. 5/16" help.

as to the question of empty stomach, I have never tracked or correlated empty stomach with erection success.

are you suggesting that an empty stomach helps with something injected straight into penis?

Thanks for the excellent replies!

Usually, we mention empty stomach with the use of Viagra, which requires an empty stomach to be most effective. I suspect Steve may be a little confused... If the 5/16 works now, it will work fine with the plumping. Try the 5/16 first.

Sure, try the .3, it'll help you dial it in faster. Glad you found success with this method. Let us know your progress and what you end up using, as far as dose goes.

What is the risk associated with more than 3x per week or 2x per 24 hours?

OK guys, thanks again for all of the helpful responses!

it looks like .03 is the magic number, but now I cant seem to ejaculate/orgasm, any suggestions here?

Thanks so much for your help and patience.

PS this board (for the most part) has been far more helpful and seemingly informed than my uro.

When you say you can't now, when last could you easily? Is this related to your starting to use Trimix?

Well, honestly, I can't see how a dependably hard erection can be any cause of failure to climax, as opposed to a hit or miss, works or not approach using the same drug. When it worked before using trimix, did you have the same difficulty? You said in your first post:

I have occasionally excellent results with Tri-mix. But it either works unbelievably well or doesn’t work at all (50% success) In this case did you have difficulties then? How long has it been that you have had to depend on the drugs to make you erect? Any previous, before that time, experiences with failure to climax?

Ok, here's my take on it, just my opinion. First, this problem is more common as we age. (General statement #1) I think if we polled it, we would find a significant number who has difficulty gaining a climax as they get older. Some easy things to blame would be boredom (sorry, girls) , worry that we might not be able to perform, resulting in a self-fulfilling prophecy, loss of sensitivity after major treatments (remember, I'm speaking of possible experience of prostate cancer guys, who can have very large and serious ED issues with any of the various treatment options, probably much the same with some options for drug side effects from Parkingson's treatments. That's just general possibilities, and not all of them.

Now, it has been my experience with trimix that it does have a slight numbing effect when I use it, I think in my case, it's the alprostadil in it, which is known to cause aching and or pain, so I always get a slight amount of the aching which can be distracting when having sex. This, I suspect may be your problem. You haven't had a lot of successful episodes yet, so this may not amount to much evidence as you continue to use it. I would suggest that you continue decreasing the amount of trimix to the point that you can have a repeatable erection lasting around an hour. Maybe with less use, the problem will solve itself.

There is another alternative, if you wish to try it, and if you think the trimix is causing a problem big enough to go with something else. As you probably know, the bimix is the same thing without the alprostadil. If it worked to give you the erection, you might find that it doesn't affect you the same way. You use more but have less side effects.

I hope this has given you some ideas to followup. Good luck, report back with results...