Why such a big PSA jump in 2 weeks and MRI thoughts...

I'm 49, and my PSA has been steadily going up the past few years - had a biopsy in May 2011 that was negative, but since it keeps going up my doc ordered an MRI and at the same time had me take antibiotics for 2 weeks to see if that made a difference - boy did it - in two weeks I went from 3.3 to 4.8! Not the direction I wanted. I am scheduled for another biopsy in 4 weeks (they are booked solid).

Here's my stats:
49 years old
Jul 2008 PSA 1.5
Sep 2009 PSA 1.9
Nov 2010 PSA 2.4
May 2011 PSA 2.9 (free PSA 3%) - Biopsy done - Negative.
Oct 2011 PSA 3.1 (moved to new city, new doc)
Jan 2012 PSA 3.3
Feb 2012 PSA 4.8 - just two weeks later!

As you can see it's been a very consistently rising at a very predictable steady pace, then all of the sudden, bam in two weeks! Could the antibiotics have done something? Is it just an anomaly? I'm having another run in a week just to ease my mind.

Also - here's what my MRI says - sounds like something is there, but if I have to look on the bright side, I think it's early????


PROSTATE:
The prostate gland measures 3.6 x 2.1 x 3.1 cm in greatest transverse, AP, and craniocaudal dimensions respectively.
Peripheral Zone: Within the peripheral zone of the prostate gland anteriorly in the mid gland just to the left of midline, there is a 6 mm T2 hypointense area that demonstrates rapid wash in/washout kinetics and restricted water diffusion.
Also on series 14, image 11 in the posterior midline immediately behind the urethra at the level of the mid gland, there is another 4-mm T2 hypointense area with restricted water diffusion. On dynamic imaging, this demonstrates early washin relative to
other areas of the prostate gland when dynamic images are directly observed on the iCAD workstation although the color mapping does not reflect this rapid kinetics.
Central Gland: There is mild enlargement of the central gland.
EXTRAPROSTATIC ASSESSMENT:
Periprostatic Fat: There is no irregular bulge of the prostate capsule. No tumor is identified penetrating through the low T2 signal intensity prostate capsule. The bladder, rectum, and pelvic sidewall are free of tumor invasion. The neurovascular
bundles are free of tumor.
Seminal Vesicles: Normal T2 hyperintense signal intensity is maintained in the seminal vesicles although evaluation is suboptimal as they are incompletely distended.
Pelvic Lymph Nodes: There are no spherically shaped nodes in the obturator, external, internal, or common iliac node chains. All identified nodes maintain short axis measurements less than or equal to 6mm.
Pelvic Bone Marrow: There is heterogeneous marrow signal intensity in the bones of the pelvis. There is degenerative disc disease at L5-S1.
IMPRESSION:
Two small distinct areas suspicious for prostate cancer as above.
One is just to the left of midline in the anterior mid gland at the junction of the central and peripheral zones.
The other is in the posterior midline peripheral zone at the mid gland immediately behind the urethra.
No evidence of extracapsular disease.

Is that good???

Thanks for any thoughts and input.

I would ask about a "saturation biopsy" which takes up to 40 samples and is done differently, a different path, not through the rectum..It's done under general anesthesia so there is no discomfort. It can reach areas the standard biopsy procedure can not..It's considerably more expensive but it seldom results in a false negative like the standard 12-core biopsy can...

A "Color Doppler Ultrasound" guided biopsy, in the hands of an expert, is another choice to consider..I would not give up on this until I had an answer...SOMETHING is going on with your prostate gland...

What did you do before the last psa test?