Just so u know :(

His psa is now 81 it was 78 his psa test are done every 3 weeks they consider this stabilized psa . Thank you all for explaining i think i get the gist of it now lol:) the reason I asked was I did the Sloan and Kettering prediction tool Prostate Cancer Nomograms i called our care manager and asked if it was accurate and she said yes but with him going in to the mdv3100 trial to add 3 months to it although it is not the same one our onc uses it is the same results of 12 months 9 months with out treatment but to understand that not everyone is the same but from my husbands bad response to past chemo drugs it is probable that the 12 months is fairly accurate. we have also had to take into account his weight loss his loss of muscle mass and his just plain tired of treatment and his lack of appetite and his desire not to take anything to stimulate his appetite we have discussed this over the last few days and he says he is fine with it he has no desire to change the outcome of this or to try that once the mdv3100 stops working he will not be doing anything else it is really sad but i do understand after 4 years he is just tired and I respect that he will be going for quality over quantity and I guess it is about time he did and do somethings he has been to sick to do
Thank you all for everything I will be still posting results of mdv3100 trial as we go along
I wish everyone the very best and pray for all of you that a cure is found soon
best wishes and low psa
C.C.

ps results of prediction tool

Your Results

Learn more about your results below.
Survival Probability 1 Year 35%
2 Year 8%
Median Survival Months 9
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I am so sorry to read of your / your husband's situation. Hopefully the MDV3100 will provide better results than the other things you have tried, and stop this monster for a while. i hope you get a break.

C.C.

Our best thoughts and prayers go out to you and your hubby.

So so sorry to read how difficult this is for you two.

Savor each and every day in every possible way you two can.

HUGS!

Bud and Mrs. Bud

Here is hoping that you get a good response from the  MDV-3100, may you be pleasantly surprised.

c.c.

Nomograms are statistics. They are a large compilation of historical results. When the nomogram is presented with data that is outside of the large "average" cases, they have a hard time giving good predictions.

I'm not saying what was reported to you is not accurate, but I am saying there are most likely not enough data points to give a good answer.

I have run my numbers through multiple times. At times it has depressed me, and at times it has left me hopeful. But at the end of the day, what result the thousands of other men have had may not be the result I will have.

We have seen men defy the odds here. Men with PSA's of several thousand, and mets, now have low PSA's and disappearing mets.
They are defying the nomograms.

Nomograms were developed from case files prior to the plethora f drugs we see coming on the market. It truly is a new world in the PCA community.

I hope that you can somehow keep fighting this thing for and with your husband. I know he is tired, and it is easy to become discouraged. Just know that all of us here on HW are pulling for you guys. Even if the MDV 3100 doesn't work the way you hoped, there are more bullets in the guns.

Mary here,

c.c., i am saddened to read your post, my heart goes out to you and your husband.

I truly understand what you are going through but do want you know you are not alone in this.

Hopefully, the trial will help in some ways.

As I said, another day with Willie was a day with sunshine, even the difficult days.

Make the most of your time together and always remember that where there's life, there's hope.

Love deeply, find some humour, somehow and laugh ( it's good to keep one's spirits up).

You are both in my thoughts and prayers, best wishes sent
daily.

Reiterating your prayers and hopes for the other members of this horrid club, may they stay as healthy as possible for as long as possible.

Love, Mary

I second (ok, Raddad beat me to it, so I'll "third") Goodlife. Those prediction tools describe outcomes from men diagnosed in previous years. Statistical models predict outcomes well on average, when the world you're predicting (what will happen to your husband in the next few years) is consistent with the world the model was built on (what happened to men in the past).

There has been dramatic progress just recently and there's more in the pipeline, so much so that I believe that the averages that were calculated based on men diagnosed years ago probably won't apply to those of us using those tools today to try to make the best decisions about our tomorrows.

And I say this not just as a wife who hates the predictions those tools make for my husband, but also as a researcher who spent most of my career building predictive statistical models. I did that for manufacturers, so they could predict how many cookies, bottles of detergent, etc. they'd sell. The hardest category to predict was prescription drugs, because the history, the old results we wanted to use to predict the future, would become obsolete every so often when a new drug or diagnostic test changed things up. I feel like I just took a crash course in prostate cancer over the past month, and wow, it is evolving really quickly.

My heart breaks for what you and he are going through, and I absolutely understand his thinking. But please don't let those predictions steal your hope -- there are a lot of reasons to believe he'll do better.

c.c.,

Just remember that as quickly as things can turn on a dime in a negative way,
they can turn back just as quickly in a positive way! :)

Keeping you in thoughts...

Prayers for you and your husband C.C!