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quad mix frequency of injection

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Posted 9/12/2012 11:57 AM (GMT 0)
I have been using the quad mix very successfully but was advised to use it only three times weekly. I must admit I have tended to use it more often. has anyone had experience using this or the trimix at a more frequent rate. If so how often. I have been using it for about 4 months. how many years has anyone been using it. any advice would help but I think it is a wonderful thing. no problems once I got the technique down
Posted 9/12/2012 12:27 PM (GMT 0)
Welcome to HW. There are quite a few here using injectables, so you should get feedabck pretty quickly.

My instructions on trimix were no more than 3x a week, with at least 24 hours between injections.

Posted 9/12/2012 1:29 PM (GMT 0)
If I'm not mistaken - the reason to NOT over use the product is to avoid scar tissue that could lead the the "what ya call" it disease where your penis can be crooked/bent and maybe unusable for intercourse.

Wouldn't have to tell me twice to be careful.
Posted 9/12/2012 10:14 PM (GMT 0)
Dr. John Mulhall says there is no evidence that shows scarring occurs from injection therapy as long as you
a.) switch sides each time and
b.) don’t inject more than 3 times a week.
Posted 9/12/2012 11:09 PM (GMT 0)
The latest thinking is that you can inject once a day. That is what we have our men do and they have never had any issues. The connection between injections and Peyronies has never been established.
Posted 9/24/2012 9:03 PM (GMT 0)
I had used trimix up 20 units and i have no reaction
This trimix is phetolamine 30 MG/ paverine o.5MG/prostaglandine 10MCG/ML Vial
I will to up 30 units
Posted 9/24/2012 9:53 PM (GMT 0)
Alberto

Welcome to HW.

It would be best if you start a new thread, and give us your PCa background, so that guys with similar experience can chime in to help.

I would say that going from 20 to 30 in one step could be very risky. My uro advises steps of no more than 10%. For me, a change from .10 to .13 was enough to generate a departure for the emergency room.

Did your Uro work with you on the first injection, and coach you on method & amounts?

Posted 9/24/2012 10:40 PM (GMT 0)
kiddoca, if you don't mind, would you tell us what the 4 ingredients in your quad mix is, and preferrably the ratios of the drugs.
Posted 9/25/2012 12:33 PM (GMT 0)
I am not at all sure of the exact mix. I just picked up the Rx. I use the quad mix at the same time cialis daily and viagra. It seems to work just fine. I get an erection that last 2 hours minimum. The question is is the cialis and viagra interfering with the function of the quadmix and causing it to become less available. if I did not use the viagra/cialis would the erection last longer. I am not sure as I know one of the ingredients of the quad mix is closely related to the ingredients in viagra and cialis. I guess the proof is that it works fine. I have discussed frequency of usage with the ED specialist at my urologists office and she says that she has patients that use it daily. My hope would be to use it as often as I wish. which I intend to do.
Posted 9/25/2012 3:48 PM (GMT 0)
Thanks for the reply. In answer to your question, I think almost all ED experts, doctors and experienced users would say to not use an injectable with the pills. Given that you are doing so, I will have to guess you have been very fortunate that you haven't gone over 4 hrs, and had to got to the ER for a reduction. Since you don't know the ingredients of the quad mix, it's impossible to say if the drugs are like or similar. I'd suggest first to ask your prescribing doctor about using the pills with the injections. Second, I'd ask the doctor or the compounding pharmacist to write down for you the exact chemical names and the amount per ml of each of the 4 drugs. Then you should be able to tell about like drugs and such.

By the way, Viagra's chemical name is sildenafil citrate, cialis is tadalafil, Levitra is vardenafil, and Staxyn is vardenafil hydrochloride.
Posted 9/25/2012 5:05 PM (GMT 0)
I believe the pill increase the blood flow to the penis and thus might decrease the duration of the erection by increasing the washout of the med. the proof is in the facts. I wil try to use it without the drugs and see what happens. it may actually increase the erection time. but we will see
Posted 9/25/2012 6:30 PM (GMT 0)
Kiddoca,

Actually, all the drugs we are talking about here do more or less the same thing.* They all work to relax the smooth muscles in the arteries in the corpus cavernosum. The injectable drugs do so directly. They act on the arterial walls to make them relax which lets your blood pressure make the arteries inflate. The pills suppress an enzyme called Phosphodiesterase 5 that destroys cGMP which is the substance that your body releases when you are sexually excited... to relax those same smooth muscles in the arteries in your Johnson.

You might ask your urologist if combining the quad mix with the Viagra is really doing much for you. You might be able to get the same bang (so to speak) for fewer bucks if you skipped the Viagra on quad mix days and adjusted the dose to compensate.

*unless the fourth drug in your quad mix is Lidocaine (four-drug mixes w/ an anaesthetic are usually still called Trimix).
Posted 9/25/2012 6:55 PM (GMT 0)
PeterDisAbelard, tell me more about the theory behind using lidocaine as a fourth drug. That's an interesting combo...
Posted 9/25/2012 7:45 PM (GMT 0)
James,

Of the three drugs used in Trimix -- Papavarine, Phentolamine, Alprostadil (aka Prostaglandin) -- the best one is the Alprostadil. It gives the strongest effect with the smallest dosage and has the fewest side-effects overall. Unfortunately, it does have one problematic side-effect for some men: it hurts.

If you are one of the one men in three for whom prostaglandin causes a pain response you won't be able to use it as a single ED drug (Caverject and MUSE will be a problem) and the relatively smaller amount in Trimix may still give you an ache. If it does you can try Bi-mix (w/o the Alprostadil) but it doesn't work as well and, at an effective dose, tends to have more of the other side-effects.

Another option is to add a dab of anesthetic to the mix (I think it is usually Lidocaine). This numbs the nerves to the corpus cavernosa but doesn't tend to affect the penile sensory nerves as much. My urologist gave me a scrip for some but I haven't filled it yet since I still have a few weeks of my previous Trimix formula on hand and I am too cheap to throw it away -- I'll just play through the ache until the vial is gone.
Posted 9/25/2012 8:21 PM (GMT 0)
Great answer and good reasoning on the medical aspect. Be sure to let us know when you do try it, I'd be interested in knowing if the ache is gone and how you feel and respond to a little numbing.. wink
Posted 9/11/2013 10:57 AM (GMT 0)
lidocaine would be the best choice since it is also a vasodilator, another possible ingredient to add would be duraclon which is injectable clonidine. Phentolamine and clonidine are specifically alpha blocker drugs which means more arterial rather than venous dilation. Phentolamine is more medically limited in use compared to old days when we used it to improve blood flow to distal limbs that were ischemic. Clonidine is costly but used in Europe. Lidocaine makes total sense to include in any injection. Prior to prosthesis placement but under anesthesia (my occupation), I have watched urologists inject 20-30 mls of normal saline to determine erection size and then chosen the appropriate prosthetic appropriately. Dorsal penile nerve blocks are done to provide pain relief, but they do also augment blood flow by blocking sympathetic nerve fibers. The anti-dotes for priapism are drugs that increase sympathetic tone such as cough meds.  Lidocaine and alpha blockers are mainstays from my perspective of injectables, not sure about the atropine.
Posted 9/11/2013 3:21 PM (GMT 0)
Welcome to the forum, Finish Strong, and thanks for the interesting observations.

What brings you to our forum? We focus primarily on prostate cancer but we will frequently have discussions on topics (such as this thread on intercavernous injections for ED) that deal with side effects of PCa treatments that are also of general interest to people outside our usual pool of participants. In any event, welcome, and if the reason you found yourself here is something you'd like to talk about feel free to say so, either by commenting further on this thread, starting a new thread or sending me an email (click the envelope icon under my name on the left).

Since you are a medical professional, you should remember that you are not participating in this forum in that capacity. It's not that we don't value your knowledge, its just that we don't want to find ourselves up to our keisters in lawyers.
Posted 9/11/2013 4:31 PM (GMT 0)

Kiddoca: the amount of each drug is on the label of the rx you picked up.

Here is an example of the label and how them meds are listed.  Each pharmacy might be different, however, by law, the medications must be listed.

VIEW IMAGE

Posted 9/11/2013 5:35 PM (GMT 0)
I've seen Quad Mix where they add forskolin. Similar to alprostadil and papaverine, it increases cyclic AMP, which relaxes cavernous smooth muscle, allowing for an erection.
Posted 9/11/2013 5:48 PM (GMT 0)
Sunshine,

This thread is coming up on an anniversary; it will be one year old tomorrow. Kiddoca seems to have only popped in for that one day last year.

Kiddoca,

Inactive members are always welcome to return and tell us how they are doing.
Posted 9/11/2013 6:25 PM (GMT 0)
I see that now. It was FinishStrong's post that made me think it was a new thread.
Posted 5/29/2017 4:59 AM (GMT 0)
Help. I have ben through the standard now super trimix and bought a pump and ring STILL to no avail! I do have CHF but have a pacemaker and have been cleared with my cardio for easy sex. I can ********* with semi rigid to ejaculation, but cannot get hard when it counts. I keep the trimix in the freezer and on ice and use a diabetic needle I have tried from 10 to 80 and...nothing... should I try a half inch needle? I have a script for the quadmix I am hoping last chance.
arrrrrgggggg help please
Posted 9/21/2017 2:13 AM (GMT 0)
I use quad mix and am curioius what has been people experience as far as loosing effectiveness un refridgerated. I might need to have it out of fridge for 5 hours and then return. Any one have any experience that would show one way or other.
Posted 9/21/2017 3:00 AM (GMT 0)
I used trimix rather than quadmix but I think they are both similar in terms of non-refrigerated stability. When I needed to have my trimix out of the fridge while I was traveling I did one of two things: For short trips I would draw a shot or two and freeze them*, putting the syringes in plastic toothbrush cases in an insulated bag with an ice pack. For longer trips where I needed to take the whole vial I used the same insulated bag and ice pack. The component of trimix that is unstable is the alprostadil which needs refrigeration after it is rehydrated. (It is stable in dry form which is how your pharmacy stores it.) Alprostadil doesn't break down into anything bad -- mix that has been warm too much won't hurt you -- it simply loses a percent or two of its effectiveness for each hour at room temperature.

*to freeze a filled syringe make sure you put them needle-up and leave a small air bubble so the mix can expand as it freezes without dribbling out.
Posted 9/21/2017 5:30 AM (GMT 0)

PeterDisAbelard. said...
I used trimix rather than quadmix but I think they are both similar in terms of non-refrigerated stability. When I needed to have my trimix out of the fridge while I was traveling I did one of two things: For short trips I would draw a shot or two and freeze them*, putting the syringes in plastic toothbrush cases in an insulated bag with an ice pack. For longer trips where I needed to take the whole vial I used the same insulated bag and ice pack. The component of trimix that is unstable is the alprostadil which needs refrigeration after it is rehydrated. (It is stable in dry form which is how your pharmacy stores it.) Alprostadil doesn't break down into anything bad -- mix that has been warm too much won't hurt you -- it simply loses a percent or two of its effectiveness for each hour at room temperature.

*to freeze a filled syringe make sure you put them needle-up and leave a small air bubble so the mix can expand as it freezes without dribbling out.

OK

Ok, I have extreme pain with trimix. Told it is the Alprostadil that makes the pain and try bimix. If I leave the trimix not refrigerated will the Alprostadil degrade to the point it will not cause the pain?
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