Posted 5/29/2013 1:42 AM (GMT 0)
Salvestrols
In 2002, Gerry Potter, Professor of Medicinal Chemistry at DeMonfort University Leicester School of Pharmacy identified and outlined a nutritional rescue mechanism that linked specific compounds in some of the most common foods we eat with cancer cell death. This rescue mechanism hinged on the metabolic activity of a certain cytochrome P450 enzyme, CYP1B1.
Importantly, this enzyme was found to be expressed by all cancers, regardless of oncogenic origin, while being absent from healthy tissue. It is now widely regarded as a universal cancer marker.
It was found that CYP1B1 metabolizes a specific class of dietary compound that Professors Potter and Professor Dan Burke (Professor Emeritus of Pharmaceutical Metabolism), named Salvestrols. When Salvestrols are metabolized by CYP1B1, new compounds are produced that actually cause apoptosis, or death, in the cancer cell.
What foods are we talking about?
A seemingly random collection of unrelated foods produce natural compounds to ward off attacks by fungi or predators. The most notable natural compound is probably resveratrol which is produced as a defence mechanism by red grape skins. But there are many others. Although these foods contain sugars which attract the predators, they tend to be bitter.
The list of foods includes: Broccoli, cabbages, kales, savoy, brussels sprouts, cauliflower, kohlrabi, chinese leaf, spinach, chard, lettuces, watercress, green beans, broad beans, garden peas.
Artichokes (globe), red & yellow peppers, beansprouts, celery, salad rocket, avocado, pumpkins, squashes, gourds, marrows, zucchini, cucumbers, melons, gherkins.
All red fruits such as strawberries, raspberries, grapes:and plums plus blackcurrants, redcurrants, blackberries, blueberries, mulberries, cranberries, bilberries.
Apples, pears, pineapples.
And herbs such as parsley, sage, rosemary, thyme, basil and mint.
In the Journal of Orthomolecular Medicine Vol 25, No. 1, 2010 (with authors Brian A. Schaefer, D.Phil.,Catherine Dooner, B.A, M. Danny Burke, Ph.D, Gerard A. Potter, Ph.D) there was a presentation of case histories involving five cancers, breast; prostate; colon; liver; and Hodgkins lymphoma. To quote the authors, Two of the cases show how rapid and dramatic the improvement can be when nutritional deficits are addressed. In each case of the five studies the patient used Salvestrols to significant effect
Modern Nutritional Deficiencies
Salvestrols operate through a highly targeted mechanism that hinges on their metabolism by the universal cancer marker CYP1B1. Most usually this simply makes up for previous nutritional deficiencies.
Unfortunately modern farming practices for example spraying fruits with pesticides reduces production of the natural defensive compounds. GMO foods will not need them, pasteurizing fruit juices decreases them, and modern diets simply do not include these common foods like cabbages and raspberries and so people lack the important phytonutrients.
These phytonutrients are all phytoalexins and are not induced in abundance until the plant comes under attack from infection or predation. If modern farming prevents the attack through spraying or GMO then the phytoalexins are simply not made.
Pro-drugs
Salvestrols operate as natural prodrugs, completely targeted to killing diseased cancer cells while leaving the normal cells alone. Initial research indicates that this mechanism could operate both preventatively, killing off cells as they become cancerous, and therapeutically, killing off cells that are part of active disease. (i.e. Prevention and Correction).
The authors of the above paper conclude Within the context of a nutritional approach to treating cancer, this mechanism appears to significantly reduce cancer cells in the body and thus increase chances of a beneficial outcome for a cancer sufferer. It is also true that when one chooses to utilize Salvestrols in combating this disease, a broader nutritional approach will aid in the efficient operation of this rescue mechanism. Co-factors such as biotin, vitamin C, vitamin B3, magnesium and iron are all known to be important. Other nutritional components, such as fatty acids, probiotics and selenium, also play important roles.
Specifics
Resveratrol has been shown to be attacked by an enzyme unique to pre-cancerous and cancer cells to produce a toxic substance (piceatannol) which brings about cell death. The anticancer agent piceatonnal is caused by the cytochrome P450 enzyme CYP 1B1. (Br J Cancer, 2002; 86: 774-778).
English Rodger.