Zytiga and Xtandi Failure

I moderate an online support group for men and their caregivers with advanced prostate cancer. A number of questions have come specific to an experience some have had. Men have reported that their PSA has declined significantly while their scans demonstrate disease progression. Their question is has the drug failed them despite the declining PSA? The simple answer is yes, with one exception (first follow up scan for men with bone lesions).

I have posted a full explanation at the advanced prostate cancer blog (www.advancedprostatecancer.net)

Joel

Dreamer44,

Your husband is very lucky to have you and your support.

I would not give up on Zytiga too fast as there does seem to be men who take a month or two to respond. However, given the situation you should be thinking and talking with your oncologist about his next step. Do raise the question with the doctor about his going back to chemotherapy again as some men who stop responding will again respond after they have failed another treatment.

Good luck

Joel

That weblink to Zytiga information was nicely informative on its usage and side effects and mechanisms of how it works, etc. It can raise Alk-Phosp. but that is not necessarily bad I gather, when using this drug, but if not using it Alk-phosp. you want to see in normal levels.

Alis,
First, let me say as the wife of a man wth PCa and mets, you have found a good place to come for answers to you questions and support from others, so welcome.
Small problem though, in that you don't tell enough about your husband's diagnosis and past treatment for utilise here to give you some suggestions.
Also, you have found a very old thread that has information that may not be the most current.
Let me try to help with your next post:
At the top of page there is "post a new topic".
Go there and give it a title. Like" I'm new and husband on xtandi."
After that, tell us everything you can. Like age, when dx, psa then and now, imaging results, medications prior to xtandi. Is he on Lupron too?
It is more likely his muscle loss and weakness is due to loss of testosterone. If he is less active appetite also goes down.
Keep posting. Don't let my questions scare you off.
Good luck!
Beth