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Is there anything after Chemo?

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Posted 1/31/2014 7:45 PM (GMT 0)

A few years ago my little brother had his prostate removed.   He was a Gleason 9, PSA 7, with bone mets.  Since then he has had radiation and most drugs under the sun.  Is now on a trial of a combo of Chemo agents.

I am so scared for him, but he is so matter a fact about the whole thing.  He makes me proud.  Wonder how he really feels?

Anyway, is there anything after Chemo?  

Thanks

Roy

Posted 1/31/2014 7:54 PM (GMT 0)
The U.S. Food and Drug Administration approved enzalutamide in 2012 for use in men with advanced prostate cancer who have received chemotherapy. The drug is a type of hormone therapy called an androgen receptor blocker.

http://www.newsmaxhealth.com/Health-News/enzalutamide-prostate-cancer-drug/2014/01/28/id/549547#ixzz2s0XW08KU
Posted 1/31/2014 7:59 PM (GMT 0)
He used it for over a year, stopped working.
Posted 2/1/2014 12:03 AM (GMT 0)
There are other things in the works that he may get through clinical trials ... google XL184, ipilimumab, and PSMA ADC for an example of three that are on my radar. You might go through the clinical trials database and search for prostate cancer to see what other ones are available. XL184 in particular addresses bone mets; I had a support group brother show dramatic response in diminishing bone mets.

Bless you both ... I can't let me little brother get this.

Ray
Posted 2/1/2014 12:31 AM (GMT 0)
PROSTATE CANCER PIPELINE REPORT Nov. 20, 2013
Phase III or Application Pending
cabozantinib / Cometriq / XL184 approved for thyroid cancer / Phase III prostate cancer est.2014?
custirsen sodium (OGX-011) Phase III (Aug.2012) blocks clusterin, cell survival protein (fast track) OncoGenex
Prostvac / Prostvacf vaccine in trials Phase III (Nov.2011) aka PSA-tricom vaccine (fast track) Bavarian Nordic (2015?)
Tasquinimod (TASQ) Phase III (2010) prostate cancer anti-angiogenesis med Active Biotech (2016?)
orteronel / TAK-700 androgen synthesis inhibitor in trials Phase III (2012) CYP-17 target Takeda Pharm.
ProstAtak vaccine by injection into prostate Phase III (Sep.2011) with radiation Advantagene
ARN509 Phase 3 (Sept.2013) androgen receptor agonist ( JNJ from Aragon) est.2017-2018?
DCVax®-Prostate autologous vaccine suspended pending partner financing
Phase II
ODM-201 androgen receptor agonist early Phase II
PSMA ADC Phase II antibody drug conjugate (ADC) with chemo/ poison
OGX-427 heat shock 27 inhibitor Phase II prostate cancer with prednisone
galeterone / TOK-001 Phase II CYP-17 target plus androgen receptor antagonist
Capesaris (GTx-758), oral nonsteroidal estrogen receptor agonist early Phase II
AEZS-108 Phase II targeted therapy with cell poison
NX-1207 injection into prostate tissue Phase II early cancer, Phase III for BPH

PX-866 inhibitor of the PI-3-kinase Phase II prostate cancer
CV9104, the RNActive cancer vaccine Phase IIb Germany
MLN8237 oral med for neuroendocrine or mcrpc prostate cancer Phase II began Feb. 2013
BIND-014 nanoparticle with docetaxel / Taxotere Phase II in USA
CV9104 immunotherapy CureVac Germany
177Lu-J591 radio-immunotherapy in trials PSMA target

Phase I
DSTP3086S anti-STEAP1 ADC Phase I prostate cancer (Zimac trial) Roche
APC-100 Phase I/II APC-300 preclinical
INK128 in trials mtor inhibitor Phase I prostate cancer
Ad5-CMV-NIS gene therapy plus radioactive iodine Phase I Mayo Clinic
Kevetrin / Thioureidobutyronitrile P53 target in Phase I solid tumors
OTS167 to fight cancer stem cells
INO-5150 PSMA vaccine to enter Phase I/II trials Inovio / Roche
BPX-201 dendritic vaccine plus booster drug Bellicum Pharm.

MISC.
JX-594 virus that infects/kills cancer cells Phase II some cancers.
ganetespib heat-shock 90 treatment in Phase III some cancers
There are many lesser known meds in trials for prostate cancer.
There are scores of trials for new meds for solid tumors and unspecified cancers.

Post Edited (robertC) : 2/3/2014 2:15:55 PM (GMT-7)

Posted 2/1/2014 12:42 AM (GMT 0)
Stoney,

I have 4 older brothers and wish one of them would be so interested. Good for you.

What has his recent scans look like and how has his psa been so far. Xofigo is a major player and acts like a smart bomb for bone Mets....as my friend Robertc shows, there are a lot of options.

Provenge yet?

Jerry
Posted 2/2/2014 1:01 AM (GMT 0)
Acceptance, all life is temporary
Posted 2/3/2014 3:30 PM (GMT 0)
I knew I could get some other things from this group to do more research. He has been in clinical trials for at least 3 years now. He had 3 bone mets at surgery and then 11. Trials shrank them at first, but now too many to count. Not sure what his PSA is not, afraid to ask. Fauntleroy, I do understand life is temporary and I understand that we each, with or without PCa, should live life to it's fullest, but it is difficult to do that when facing something like mets.
Thanks Ksargent, Ray, RobertC, Jerry and Fauntleroy for your interest.

Roy
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