Palatin ED drug PT-141 - Anyone have info?

Palatin Technologies was trying to get FDA approval several years ago for an ED drug labeled PT-141 (bremelanotide), but I haven't heard much about it since the FDA dumped approval during the phase 3 trials due to BP spiking.

However, it seems they are marketing it or something similar as an subcutaneous female sexual arousal drug. I don't see anything that indicates it is FDA approved, but you can buy it on-line easy enough although they do state it is for experimentation only.

It seems to be approved in Europe. Anyone know anything more about this?

Jim

Here are a couple of recent studies.

http://www.ncbi.nlm.nih.gov/pubmed/24770160

http://www.ncbi.nlm.nih.gov/pubmed/24770153

dmlvt,

Yes, it's the potential to help with the 'untreatable' side-effects of ADT that caught my attention. With pills, pumps, injections and implants there are almost always ways to work around ED if a man is sufficiently motivated, but if you need help with motivation there's nothing.

jimO/dm,

Over on FrankTalk.org there was a brief couple of threads discussing PT-141 from people who had used it ( a couple of years ago).

To find the threads use the forum search over there and just put in 141 .. not PT-141 (will not show anything for some reason).

It looked promising as a boost mechanism.

J

Post Edited (JStars) : 6/29/2014 8:44:21 AM (GMT-6)

Update to previous posts - PT141 is not approved in Europe or anywhere else that I can see. Palatin (the manufacturer) has licensed an unnamed pharmaceutical company to market it in Europe when it is approved, but as best I can tell, their license expired in April 2014, and approval is nowhere in sight.

It is available (for experimentation purposes only) on several websites, ranging in price from about $25 to over $100 for a 10 mg vial, supplied as a powder that is reconstituted with bacteriostatic water and injected subcutaneously. After reconstituting, it needs to be refrigerated.

I bounced around at least twenty different websites, and it seems like many folks have tried it, with some spectacular results as well as some bona-fide disasters (nothing life-threatening, but erections at random intervals can be pretty embarrassing.)

It's basically a female arousal drug, but almost everyone I found that tried it was male, many from penis enlargement sites. It works by enhancing sexual arousal in the brain and thus, it is very different than typical ED drugs which stimulate erections by enhancing blood flow to the penis.

Anyway, it's real and the general consensus is that it works rather well. However, it is extremely dose sensitive and anyone thinking about trying it, should carefully to do their homework regarding both supplier and dosage, and also consider that it is not a legal drug anywhere. Some of the sites selling it can't write a coherent sentence in English, are totally unaware of its method of action, and provide misleading information.

Jim

Peter

Thanks for the info and link to the 2013 thread. I read the NY Times article as well as the entire thread. As a relatively new member of HW, I am amazed at the level of intellect of its members. The thread was extremely interesting and informative.

As far as the absolute efficacy of Lybrido and Lybridos compared to Bremelanotide (PT-141), I think the PT-141 will come out on top as far as efficacy, but not marketability. A pill that works is obviously going to be much more marketable than an injectable drug. In any event, it is unlikely we'll find out much more until more studies are published.

I'm highly interested in this mostly for my wife. A little history -- we have been together for about 35 years, second marriage for both of us. Until about 15 years ago, we were a sexual dynamo team, making love 7-10 times/week regularly (honest) for more than 20 years.

Then her PTSD hit along with clinical depression. Her early childhood was marred by an alcoholic, seriously abusive father, and a set of equally abusive uncles with a co-dependent mother standing by to watch. Like many folks with PTSD, it hit her years later, and did a nasty job on her emotional well-being as well as our love life. She has been on many antidepressants and other medications including SSRI's that put a serious dent in her libido. For the past few years, I've been working hard to get her off the drugs and onto natural remedies with limited, but significant success.

An interesting item I gleaned from the thread and the NYT article was that a dopamine increase does not always relate to increased libido, and even when it did (with drugs like L-Dopa) it was short-lived. I noted a similar effect when she started a prescription for Trazadone. For a few weeks, she was back to her old "sexual dynamo" self, but her libido faded pretty rapidly after her body got used to the drug.

Anyway, I'm real interested in anything that will help increase her ability to cope along with her libido. Reducing the depression with nutrients and herbals (rather than pharmaceuticals) has helped significantly, but she is a long way from where she used to be.

Unfortunately, medical treatment for conditions like hers is woefully inadequate. In the area where we live, several clinics have closed due to lack of funding.

Jim

I came across a couple of articles from TheScientist magazine that talk about PT-141 (bremelanotide) among other drugs that are seeking FDA approval for Female Sexual Dysfunction. Interesting reading. The opinion expressed is that the whole industry is waiting for the first one to get approved and once that happens the money needed will quickly appear and several of the the others will get hammered through the process in short order.

It gives you an interesting competitive market where all the players are rooting for each other. I still think Bremelanotide is the most likely candidate in terms of effectiveness but they may not be the first over the line. There is another drug that has just been rejected for the second time but, after they appealed, the FDA gave them some specific things they needed to look at before they applied again. This is seen as hopeful because it gives them specific hurdles they need to clear.

Here are those links...

That Loving Feeling

Let’s Talk about Sex

Both from The Scientist, 1 July 2014 and both by Megan Scudellari.

Hello Everyone:

I would like to try Bremelanotide. But I am worried about the source and not the compound. Does anyone know of a safe or reputable supplier?