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LUPRON VS. DEGARELIX

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Prostate Cancer
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Posted 11/24/2014 8:32 PM (GMT 0)
Has anyone experienced taking both of these drugs for Hormone deprevation?

My husband had been on Lupron for 1 year. He then took a HT vacation until his PSA starting rising.
Our oncol. deceided to try Degaralix this time. He was on that for 6 monthes and his PSA started rising while on it. He had his last shot in Sept.

He just had another PSA this morning and we are almost certain of the doubling time will warrant treatment again.

Has anyone started Lupron after degarelix failed with positive results?

Thank you,

BOOGEE
Posted 11/25/2014 4:56 AM (GMT 0)
Hi BOOGEE,

I can't find the exact link, but I have read of people switching LHRH drugs to correct a poor response. So, going back to Lupron, or Trelstar, etc., might be a good option.

However, the PSA increase to .2 does not seem that radical, especially if scans don't show anything. Have you considered adding Avodart and Casodex to his Firmagon/Lupron shot as your next step?

I've been reading Dr. Snuffy Myers' book on hormone therapy again these days, and he writes repeatedly that the first thing he tries when PSA rises during hormone therapy is to increase Casodex dosage from 50mg, to 150mg, and/or switch the LHRH brands, while including Avodart to block DHT from fuelling the cancer cells.

Arthur
Posted 11/25/2014 1:10 PM (GMT 0)
Yes - I started on Zolodex, failed after about 7 months, went to degarelix, lasted about 1 year, now onto Lupron - its one year this month and still working. Sequencing on different HT drugs can sometimnes extend the time until one is refractory -- Hopefully for a long time!!!!!!
Posted 11/25/2014 3:20 PM (GMT 0)
Thanks all.

Will meet with our oncol. next month and I'm certain he will have some treatment options. It helps to talk to my brothers and sisters on HW however.

BOOGEE
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