Certainly, you'd want that PSA confirmed, but I differ from some of the above posters based on the latest data I've seen.
Your husband had two risk factors on his pathology report: ECE and positive margins. With that adverse pathology and uPSA already hitting 0.03, this will almost certainly progress to full biochemical recurrence and beyond.
With 3 major clinical trials now proving definitively that earlier treatment has better outcomes, it means that you should begin discussing this with a radiation oncologist sooner rather than later. What do you gain by waiting to begin those discussions? Here are some commentaries on recent studies about
this:
When should the patient and doctor consider salvage radiation therapy?Johns Hopkins: ultrasensitive PSA after surgery predicts biochemical relapseThe factors in his favor were his relatively low Gleason score, his relatively low PSA at the time of surgery, that he became undetectable and stayed that way for 2 years. Because of these factors, it is unlikely that the cancer has become metastatic yet. The tough part in making the decision is that if you wait until the signs are clearer (high PSA, short PSADT) it will be too late for the salvage therapy to be curative.
There is a test they can do on his prostate tissue called "Decipher" that is pretty good at predicting the cancers that won't become detectably metastatic in the next 5 years. It's not as good at predicting which ones will go metastatic in that time frame. It may help you make up your mind.
- Allen