barrettbates said...
There are probably a lot of suffering males who are courageous enough to want to know the answer to this question, just to be better prepared. I'm one of them; probably in hormone blockade refraction (it don't work no more)
Thank you.
To refine the original question a little.
I think people want to know three separate things:
1. In broad terms, the average timescales of the different stages from a given starting point.
2. The likely degree of quality of life impairment during those phases.
3. The likely care needs of the terminal phase (to help minimise impact on others)
For me this translates as:
1. a) How long am I likely to have from the point of starting anti-androgen treatment (after failed surgery and failed prostate bed radiotherapy) to castration-resistant disease. My reading suggests this is 3-5 years. b) How long after castration-resistant disease before uncontrolled decline. My reading suggests most drugs are a few months' benefit and this phase is c. 2 years c) How long a terminal phase. My reading suggests 2-6 months.
2. The first phase is the side effects of hormone treatment - well documented and reasonably manageable. Sad that I will have to give up rock climbing (weight gain + bone brittleness + fatigue =/= climbing!). The second phase has more acute side effects. The third is painful and debilitating.
3. Variable but painful and bed-bound at end stage. My reading suggests that pain can be controlled but at the expense of prolonging life without much quality. I have arrangements to avoid this stage.
The clinical studies I am drawing on are sometimes a bit dated, and the field has moved on. I would be interested if others have a different (evidence-backed) view of the timescales.
Sorry to be blunt; I'm a career-scientist so the numbers speak to me.