Lupron to Degarelix

The first dose of degarelix is usually the worst, both because it's a new drug and your body isn't used to it and because the first dose is two shots.

Some people get flu-like symptoms the first couple of days but for me it was more like the reaction from two hornet stings in my lower belly. Very uncomfortable for a few days. Ice helps, as I recall, but you can't use heat.

The worst of the symptoms usually go away after 48 hours although the odd sensation of having lumps in your belly fat like bars of soap under the skin lasts a while.

So, yes, lots of guys have reactions to their first dose. Usually it is injection site redness and swelling. But it goes away.

You'll feel better soon.

Ditto on what Peter said,

I began degerelix last June (2016). I remember the first two monthly injections well. They doubled up the amounts. The energy really took a hit and the injection area was very tender for days. I never experienced the flu symptoms. Occasionally, I experienced warm flashes and I felt like I sweated more while exercising.

I enjoy cycling and I immediately noticed I couldn't keep up with guys I previously able to hang with easily. It wasn't a cardio issue, rather my legs felt very weak and I just couldn't get past 80% level of effort. However, I continued to ride 3-4x weekly and just accepted the fact that Low-T would affect the energy/strength. I decided that instead of *****ing and moaning about it, I would press on, although at a slower pace. Plus, I began spending more time at the gym doing strength/resistance.

Initially, it was disheartening. However, once you understand this (weakness/low energy) is what happens when you rapidly lower the Testosterone levels, it all made sense. So, I just accepted I couldn't ride as fast and made up for that my lengthening my rides.

Once we went to single dosages (month 3), the energy improved dramatically, the soreness at the injection area was greatly minimized and I actually began to feel good again.

I hope this helps,

Tony